Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function

doi:10.1016/j.jpsychires.2015.04.008

CORC > 北京大学 > 生命科学学院

	Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function
	Liao Jinmin ; Yan Hao ; Liu Qi ; Yan Jun ; Zhang Lanlan ; Jiang Sisi ; Zhang Xiao ; Dong Zheng ; Yang Wen ; Cai Liwei ; Guo Huining ; Wang Yan ; Li Zimeng ; Tian Lin ; Zhang Dai ; Wang Fei
刊名	journal of psychiatric research
	2015
关键词	Paralimbic system,Schizophrenia,Structural magnetic resonance imaging,Voxel-based morphometry
DOI	10.1016/j.jpsychires.2015.04.008
英文摘要	Psychopathy is associated with dysfunction in regions that compose the paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole (TP), parahippocampal gyrus (PHG) and cingulate cortex (CC). However, findings of structural alterations in these regions are inconsistent in schizophrenia, and correlations between paralimbic system measures and symptomatology and cognitive function have not been investigated.93 patients with schizophrenia and 99 healthy controls received structural magnetic resonance imaging and clinical and cognitive assessment. We compared gray matter volume (GMV) between the two groups using voxel-based morphometry, and evaluated correlations between abnormal GMVs and clinical variables, symptomatology and cognitive function. The assessment of cognition included measures of processing speed, verbal fluency and memory.Patients with schizophrenia demonstrated significant GMV decreases in the paralimbic system, including bilateral OFC, IC and TP (p?http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000356123300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); PubMed; SSCI; 4; ARTICLE; daizhang@bjmu.edu.cn; fei.wang@yale.edu
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/164239]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Liao Jinmin,Yan Hao,Liu Qi,et al. Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function[J]. journal of psychiatric research,2015.
APA	Liao Jinmin.,Yan Hao.,Liu Qi.,Yan Jun.,Zhang Lanlan.,...&Wang Fei.(2015).Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function.journal of psychiatric research.
MLA	Liao Jinmin,et al."Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function".journal of psychiatric research (2015).