Prevalence and genetic diversity of pneumococcal serogroup 6 in   Australia

doi:10.1111/j.1469-0691.2010.03404.x

CORC > 北京大学 > 生命科学学院

	Prevalence and genetic diversity of pneumococcal serogroup 6 in Australia
	Zhuo, F. ; Xiao, M. ; Kong, F. ; Oftadeh, S. ; Zhou, F. ; Zhang, J. ; Gilbert, G. L.
刊名	clinical microbiology and infection
	2011
关键词	Antibiotic susceptibility diversity genotypes serotypes 6C and 6D Streptococcus pneumoniae STREPTOCOCCUS-PNEUMONIAE SEROTYPE CONJUGATE VACCINE UNITED-STATES INVASIVE DISEASE CHILDREN PCR ERA IDENTIFICATION EMERGENCE 19A
DOI	10.1111/j.1469-0691.2010.03404.x
英文摘要	The prevalence of the newly discovered pneumococcal serotype 6C has increased in some countries since the introduction of seven-valent conjugate pneumococcal vaccine (PCV7). The distribution of invasive serogroup 6 serotypes, in Australia, including 6C and 6D, has not been reported previously. During the period 1999 to 2008, 6097 isolates were referred to the New South Wales Pneumococcal Reference Laboratory for serotyping. Of these, 847 were identified by Quellung reaction as belonging to serogroup 6 and 702 were available for further study. Serotypes were determined by serotype-specific PCR as follows: 6A, 197 (28.1%); 6B, 452 (64.4%); 6C, 52 (7.4%) and one 6D. The average numbers of invasive serogroup 6 isolates, per annum, fell from 62.2 before (2000-2005) to 49.7 after (2006-2008) the introduction of PCV7. The proportions of invasive 6B fell (from 72.4% to 47.3%, p 0.03), those of 6C rose (from 3.3% to 17%, p 0.02) significantly and those of 6A remained fairly constant (24.3% vs 27%, p 0.69) between the two periods. All 6C and 6D and selected 6A and 6B isolates were further characterized by multilocus sequence typing and sequence analysis of cps genes cpsA-cpsB (wzg-wzh) and wchA-wciN(beta)-wciO, wciP. Results showed considerable diversity within serotype 6C, apparently as a result of both mutation and recombination. Sequence typing indicates that, in Australia, 6C has been largely derived from 6A. The genetic diversity and rapid increase in incidence of serotype 6C causing invasive pneumococcal disease has potential implications for vaccine efficacy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293030500027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Infectious Diseases; Microbiology; SCI(E); PubMed; 9; ARTICLE; 8; 1246-1253; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/159488]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhuo, F.,Xiao, M.,Kong, F.,et al. Prevalence and genetic diversity of pneumococcal serogroup 6 in Australia[J]. clinical microbiology and infection,2011.
APA	Zhuo, F..,Xiao, M..,Kong, F..,Oftadeh, S..,Zhou, F..,...&Gilbert, G. L..(2011).Prevalence and genetic diversity of pneumococcal serogroup 6 in Australia.clinical microbiology and infection.
MLA	Zhuo, F.,et al."Prevalence and genetic diversity of pneumococcal serogroup 6 in Australia".clinical microbiology and infection (2011).