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	Discovery of Non-ATP-Competitive Plk1 Inhibitors; Discovery of Non-ATP-Competitive Plk1 Inhibitors
	Taikangxiang Yun ; Tan Qin ; Ying Liu ; Luhua Lai
	2016
关键词	Inhibitors Kinase domain Non-ATP binding site Polo-like kinase 1 Inhibitors Kinase domain Non-ATP binding site Polo-like kinase 1
英文摘要	Polo-like kinase 1(Plk1)is an evolutionarily conserved serine/threonine kinase in mammalian cells that participates in multiple steps in mitosis.Its N-terminal kinase domain(KD)controls cell signaling through phosphorylation.Inhibitors of Plk1 are potential anticancer drugs.Most known Plk1 KD inhibitors are ATP-competitive compounds,which may suffer from; Polo-like kinase 1(Plk1)is an evolutionarily conserved serine/threonine kinase in mammalian cells that participates in multiple steps in mitosis.Its N-terminal kinase domain(KD)controls cell signaling through phosphorylation.Inhibitors of Plk1 are potential anticancer drugs.Most known Plk1 KD inhibitors are ATP-competitive compounds,which may suffer from; 中国生物化学与分子生物学会; 1
语种	英语
出处	中国生物化学与分子生物学会2016年全国学术会议
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/479833]
专题	化学与分子工程学院 生命科学学院
推荐引用方式 GB/T 7714	Taikangxiang Yun,Tan Qin,Ying Liu,et al. Discovery of Non-ATP-Competitive Plk1 Inhibitors, Discovery of Non-ATP-Competitive Plk1 Inhibitors. 2016-01-01.

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