Genetically Encoded Photoaffinity Histone Marks

doi:10.1021/jacs.7b01431

CORC > 北京大学 > 化学与分子工程学院

	Genetically Encoded Photoaffinity Histone Marks
	Xie, Xiao ; Li, Xiao-Meng ; Qin, Fangfei ; Lin, Jianwei ; Zhang, Gong ; Zhao, Jingyi ; Bao, Xiucong ; Zhu, Rongfeng ; Song, Haiping ; Li, Xiang David ; Chen, Peng R.
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2017
关键词	POSTTRANSLATIONAL MODIFICATIONS GENE-EXPRESSION RECOMBINANT PROTEINS METABOLIC-REGULATION ACID RESISTANCE YEATS DOMAIN LYSINE CROTONYLATION ACETYLATION METHYLATION
DOI	10.1021/jacs.7b01431
英文摘要	Posttranslational modifications (PTMs) of lysine are crucial histone marks that regulate diverse biological processes. The functional roles and regulation mechanism of many newly identified lysine PTMs, however, remain yet to be understood. Here we report a photoaffinity crotonyl lysine (Kcr) analogue that can be genetically and site-specifically incorporated into histone proteins. This, in conjunction with the genetically encoded photo-lysine as a "control probe", enables the capture and identification of enzymatic machinery and/or effector proteins for histone lysine crotonylation.; National Natural Science Foundation of China [21521003, 21432002, 21572191]; National Key Research and Development Program of China [2016YFA0501500]; Hong Kong Research Grants Council [CRF C7029-15G, AoE/P-705/16, GRF 17303114, HKU 709813P]; SCI(E); ARTICLE; 19; 6522-6525; 139
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473380]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Xie, Xiao,Li, Xiao-Meng,Qin, Fangfei,et al. Genetically Encoded Photoaffinity Histone Marks[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017.
APA	Xie, Xiao.,Li, Xiao-Meng.,Qin, Fangfei.,Lin, Jianwei.,Zhang, Gong.,...&Chen, Peng R..(2017).Genetically Encoded Photoaffinity Histone Marks.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.
MLA	Xie, Xiao,et al."Genetically Encoded Photoaffinity Histone Marks".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017).