Identification of spirobisnaphthalene derivatives with anti-tumor   activities from the endophytic fungus Rhytidhysteron rufulum AS21B

doi:10.1016/j.bmc.2017.02.054

CORC > 北京大学 > 化学与分子工程学院

	Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B
	Siridechakorn, Ittipon ; Yue, Zongwei ; Mittraphab, Yanisa ; Lei, Xiaoguang ; Pudhom, Khanitha
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2017
关键词	Endophytic fungi Rhytidhysteron rufulum Spirobisnaphthalene Anti-cancer activity Fungal cultivation EDENIA-GOMEZPOMPAE INHIBITORS PRODUCTS
DOI	10.1016/j.bmc.2017.02.054
英文摘要	The cultivation of the mangrove-derived fungus Rhytidhysteron rufulum AS21B in acidic condition changed its secondary metabolite profile. Investigation of the culture broth extract led to the isolation and identification of two new spirobisnaphthalenes (1 and 2) together with eleven known compounds (313) from the crude extract of the fungus grown under an acidic condition as well as six known compounds (4, 10, 14-17) were isolated from the crude extract of the fungus grown under a neutral condition. Their structures were elucidated on the basis of extensive spectroscopic data. The isolated compounds were evaluated for their cytotoxicity against two human cancer cell lines, Ramos lymphoma and drug resistant NSCLC H1975. Compounds 2 and 10 displayed the most promising anti-tumor activity against both cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.; Thailand Research Fund (TRF) [BRG5980002]; National Natural Science Foundation of China [21561142002]; SCI(E); ARTICLE; 11; 2878-2882; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473001]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,et al. Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2017.
APA	Siridechakorn, Ittipon,Yue, Zongwei,Mittraphab, Yanisa,Lei, Xiaoguang,&Pudhom, Khanitha.(2017).Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.BIOORGANIC & MEDICINAL CHEMISTRY.
MLA	Siridechakorn, Ittipon,et al."Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B".BIOORGANIC & MEDICINAL CHEMISTRY (2017).