Phosphatase-triggered cell-selective release of a Pt(IV)-backboned   prodrug-like polymer for an improved therapeutic index

doi:10.1039/c6bm00935b

CORC > 北京大学 > 化学与分子工程学院

	Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index
	Li, Shao-Lu ; Hou, Yingqin ; Hu, Yali ; Yu, Jin ; Wei, Wei ; Lu, Hua
刊名	BIOMATERIALS SCIENCE
	2017
关键词	NANOSCALE COORDINATION POLYMERS ANTICANCER DRUG-DELIVERY PLGA-PEG NANOPARTICLES PT(IV) PRO-DRUG CANCER-THERAPY CO-DELIVERY ANTITUMOR EFFICACY CISPLATIN PRODRUG TARGETED DELIVERY PLATINUM DRUGS
DOI	10.1039/c6bm00935b
英文摘要	We describe here the synthesis and cell-selective delivery of a cationic Pt(IV)-backboned prodrug-like polymer P(DSP-DAEP). P(DSP-DAEP) features excellent aqueous solubility, unusually high (44.5%) drug loading, can be rapidly reduced to release the active cisplatin, and is more potent than its small molecular Pt(IV) precursor DSP. P(DSP-DAEP) can be formulated with an oppositely charged methoxyl poly(ethylene glycol)-block-poly(L-phosphotyrosine) (mPEG-b-PpY) to afford a polyion micelle (Pt-PIC) by taking advantage of polyelectrolyte coacervation. Preliminary in vitro cellular uptake and cytotoxicity assays indicate that Pt-PIC exhibits receptor (surface alkaline phosphatase)-dependent uptake and cytotoxicity. Overall, our results suggest a new approach to the improved therapeutic index of platinum-based anticancer drugs via cell-selective delivery.; National Key Research and Development Program of China [2016YFA0201400]; National Natural Science Foundation of China [NSFC21434008]; Open Funding Project of the State Key Laboratory of Biochemical Engineering [2015KF-01]; China Postdoctoral Science Foundation [2016 M600847]; Postdoctoral Fellowship of the Peking-Tsinghua Center for Life Sciences; SCI(E); ARTICLE; 8; 1558-1566; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/471818]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, Shao-Lu,Hou, Yingqin,Hu, Yali,et al. Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index[J]. BIOMATERIALS SCIENCE,2017.
APA	Li, Shao-Lu,Hou, Yingqin,Hu, Yali,Yu, Jin,Wei, Wei,&Lu, Hua.(2017).Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index.BIOMATERIALS SCIENCE.
MLA	Li, Shao-Lu,et al."Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index".BIOMATERIALS SCIENCE (2017).