Fullerene/photosensitizer nanovesicles as highly efficient and clearable   phototheranostics with enhanced tumor accumulation for cancer therapy

doi:10.1016/j.biomaterials.2016.06.023

CORC > 北京大学 > 化学与分子工程学院

	Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy
	Guan, Mirong ; Ge, Jiechao ; Wu, Jingyi ; Zhang, Guoqiang ; Chen, Daiqin ; Zhang, Wei ; Zhang, Ying ; Zou, Toujun ; Zhen, Mingming ; Wang, Chunru ; Chu, Taiwei ; Hao, Xiaojuan ; Shu, Chunying
刊名	BIOMATERIALS
	2016
关键词	Nanovesicle Fullerene Photosensitizer Phototheranostic UP-CONVERSION-NANOPARTICLES NEAR-INFRARED LIGHT GUIDED PHOTODYNAMIC THERAPY IN-VIVO THERANOSTIC APPLICATIONS GRAPHENE OXIDE DRUG-DELIVERY CHLORIN E6 PHOTOTHERMAL/PHOTODYNAMIC THERAPY CARBON NANOMATERIALS
DOI	10.1016/j.biomaterials.2016.06.023
英文摘要	A novel phototheranostic platform based on tri-malonate derivative of fullerene C-70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to similar to 57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures. (C) 2016 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license; National Natural Science Foundation of China [51372251, 51472252]; Chinese Academy of Sciences [XDA09030302, KGZDEW-T02]; SCI(E); EI; PubMed; ARTICLE; jchge2010@mail.ipc.ac.cn; shucy@iccas.ac.cn; 75-85; 103
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/447899]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Guan, Mirong,Ge, Jiechao,Wu, Jingyi,et al. Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy[J]. BIOMATERIALS,2016.
APA	Guan, Mirong.,Ge, Jiechao.,Wu, Jingyi.,Zhang, Guoqiang.,Chen, Daiqin.,...&Shu, Chunying.(2016).Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy.BIOMATERIALS.
MLA	Guan, Mirong,et al."Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy".BIOMATERIALS (2016).