Oxidation and temperature dual responsive polymers based on   phenylboronic acid and N-isopropylacrylamide motifs

doi:10.1039/c5py01999k

CORC > 北京大学 > 化学与分子工程学院

	Oxidation and temperature dual responsive polymers based on phenylboronic acid and N-isopropylacrylamide motifs
	Zhang, Mei ; Song, Cheng-Cheng ; Ji, Ran ; Qiao, Zeng-Ying ; Yang, Chao ; Qiu, Fang-Yi ; Liang, De-Hai ; Du, Fu-Sheng ; Li, Zi-Chen
刊名	POLYMER CHEMISTRY
	2016
关键词	CYCLIC ORTHOESTER GROUPS REACTIVE OXYGEN DRUG-DELIVERY BLOCK-COPOLYMERS POLY(ETHYLENE GLYCOL) HYDROGEN-PEROXIDE BIOMEDICAL APPLICATIONS AQUEOUS-SOLUTIONS POLY(N-ISOPROPYLACRYLAMIDE) NANOPARTICLES
DOI	10.1039/c5py01999k
英文摘要	Oxidation stress has been becoming an important target for the development of smart nanomedicines, triggering research interest in oxidation responsive polymers. Herein, we report a new type of temperature/ oxidation dual responsive copolymer. They were synthesized by the sequential atom transfer radical copolymerization (ATRP) of N-isopropylacrylamide (NIPAM, M1) and a phenylboronic pinacol estercontaining acrylate (M2) and dialysis against water to remove the pinacol protecting groups. The copolymers with a small amount of phenylboronic acid units (< 7%) were soluble in cold neutral phosphate buffer but showed lower critical solution temperatures in the range of 12-31 degrees C. The thermally induced phase transition profiles depended on both the composition and concentration of the polymers. The cloud points of the copolymers were shifted to higher temperatures upon H2O2 induced oxidation of the phenylboronic acid and the subsequent 1,6-elimination. Using PEG-Cl as the macroinitiator to initiate ATRP of M1 and M2, three block copolymers composed of a PEG block and a temperature/oxidation dual responsive segment were prepared after dialysis in water. These block copolymers had a similar ratio of NIPAM to phenylboronic acid units but different molecular weights. We have studied their thermal selfassembly and H2O2 triggered decomposition by laser light scattering, H-1 NMR, and transmission electron microscopy. Upon a fast heating protocol, these block copolymers formed stable micelle-like nanoparticles (at 37 degrees C) that were capable of encapsulating doxorubicin (DOX) and showed H2O2 triggered release. The naked nanoparticles were cytocompatible, however the DOX-loaded ones exhibited concentration dependent cytotoxicity, in particular to cancer cells.; National Natural Science Foundation of China [21474001]; National Science Fund for Distinguished Young Scholars of China [21225416]; SCI(E); ARTICLE; fsdu@pku.edu.cn; zcli@pku.edu.cn; 7; 1494-1504; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438954]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Mei,Song, Cheng-Cheng,Ji, Ran,et al. Oxidation and temperature dual responsive polymers based on phenylboronic acid and N-isopropylacrylamide motifs[J]. POLYMER CHEMISTRY,2016.
APA	Zhang, Mei.,Song, Cheng-Cheng.,Ji, Ran.,Qiao, Zeng-Ying.,Yang, Chao.,...&Li, Zi-Chen.(2016).Oxidation and temperature dual responsive polymers based on phenylboronic acid and N-isopropylacrylamide motifs.POLYMER CHEMISTRY.
MLA	Zhang, Mei,et al."Oxidation and temperature dual responsive polymers based on phenylboronic acid and N-isopropylacrylamide motifs".POLYMER CHEMISTRY (2016).