Synthesis and mode of action of oligomeric sesquiterpene lactones

doi:10.1039/c5np00089k

CORC > 北京大学 > 化学与分子工程学院

	Synthesis and mode of action of oligomeric sesquiterpene lactones
	Li, Chao ; Jones, Alexander X. ; Lei, Xiaoguang
刊名	NATURAL PRODUCT REPORTS
	2016
关键词	NF-KAPPA-B MYELOGENOUS LEUKEMIA STEM BIOORTHOGONAL LIGATION BIOMIMETIC SYNTHESES NATURAL-PRODUCTS PPAR-GAMMA PROGENITOR CELLS QUINONE METHIDE CANCER PARTHENOLIDE
DOI	10.1039/c5np00089k
英文摘要	In this highlight we describe two case studies from our laboratory, involving the biomimetic syntheses and the biological mechanism elucidation of the bioactive oligomeric sesquiterpenoids, (+)-ainsliadimer A (4) and (-)-ainsliatrimer A (5). Ainsliadimer A possesses potent anti-inflammatory activity by inhibition of the NF-kappa B signalling pathway via binding at a previously untargeted allosteric site. (-)-Ainsliatrimer A induces apoptosis in cancer cells by activation of PPARg. Furthermore, we highlight a new bioorthogonal ligation (TQ-ligation) developed in our laboratory which facilitates the target identification of complex natural products via pre-target fluorescence imaging and affinity chromatography. Generally, this paper will discuss the complete process from total synthesis to biological studies of complex natural products, and from the establishment of new bio-orthogonal chemistry to successful target identification. Our approach provides a systematic and efficient methodology for addressing the challenge of natural product target identification.; National High Technology Projects 973 [2015CB856200]; NNSFC [21222209, 21472010, 91313303]; SCI(E); REVIEW; xglei@pku.edu.cn; 5; 602-611; 33
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438853]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Li, Chao,Jones, Alexander X.,Lei, Xiaoguang. Synthesis and mode of action of oligomeric sesquiterpene lactones[J]. NATURAL PRODUCT REPORTS,2016.
APA	Li, Chao,Jones, Alexander X.,&Lei, Xiaoguang.(2016).Synthesis and mode of action of oligomeric sesquiterpene lactones.NATURAL PRODUCT REPORTS.
MLA	Li, Chao,et al."Synthesis and mode of action of oligomeric sesquiterpene lactones".NATURAL PRODUCT REPORTS (2016).