A poly(amidoamine) dendrimer-based nanocarrier conjugated with   Angiopep-2 for dual-targeting function in treating glioma cells

doi:10.1039/c5py01625h

CORC > 北京大学 > 化学与分子工程学院

	A poly(amidoamine) dendrimer-based nanocarrier conjugated with Angiopep-2 for dual-targeting function in treating glioma cells
	Xu, Zejun ; Wang, Yao ; Ma, Zhiyong ; Wang, Zhijian ; Wei, Yen ; Jia, Xinru
刊名	POLYMER CHEMISTRY
	2016
关键词	BLOOD-BRAIN-BARRIER POLY(ETHYLENE GLYCOL)-CO-POLY(EPSILON-CAPROLACTONE) NANOPARTICLES DRUG-DELIVERY APPLICATIONS BIOMEDICAL APPLICATIONS PAMAM DENDRIMERS OPTICAL/PARAMAGNETIC NANOPROBE GOLD NANOPARTICLES PCL NANOPARTICLES IN-VIVO CANCER
DOI	10.1039/c5py01625h
英文摘要	A GSH sensitive nanocarrier (G4-DOX-Angiopep-PEG), with Angiopep-2 as a dual-targeting group and doxorubicin (DOX) as the therapy drug, was constructed by covalently conjugating them on the periphery of fourth generation PAMAM dendrimers (G4 PAMAM), aiming for an enhancement of BBB transportation and drug accumulation in glioma cells. It was found that the DOX release reached 44% with the concentration of GSH at 10 mM in the system, while only 3% DOX was released at pH 7.4 without GSH. The in vitro assay of transport across the BBB model showed that G4-DOX-Angiopep-PEG delivered 11% of DOX in a period of 12 h. The carrier could internalize into C6 glioma cells through low-density lipoprotein receptor-related protein (LRP)-mediated transcytosis. The accumulation of DOX in the tumor site was increased due to the targeting effects of Angiopep-2 via LRP-mediated endocytosis, which resulted in the volume of the avascular C6 glioma spheroids being effectively reduced in vitro.; National Natural Science Foundation of China [21274004]; China Postdoctoral Science Foundation [2015M570880]; SCI(E); EI; ARTICLE; xrjia@pku.edu.cn; 3; 715-721; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/437804]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xu, Zejun,Wang, Yao,Ma, Zhiyong,et al. A poly(amidoamine) dendrimer-based nanocarrier conjugated with Angiopep-2 for dual-targeting function in treating glioma cells[J]. POLYMER CHEMISTRY,2016.
APA	Xu, Zejun,Wang, Yao,Ma, Zhiyong,Wang, Zhijian,Wei, Yen,&Jia, Xinru.(2016).A poly(amidoamine) dendrimer-based nanocarrier conjugated with Angiopep-2 for dual-targeting function in treating glioma cells.POLYMER CHEMISTRY.
MLA	Xu, Zejun,et al."A poly(amidoamine) dendrimer-based nanocarrier conjugated with Angiopep-2 for dual-targeting function in treating glioma cells".POLYMER CHEMISTRY (2016).