In vitro and in vivo evaluation of technetium-99m-labeled propylene   amine oxime complexes containing nitroimidazole and nitrotriazole groups   as hypoxia markers

doi:10.1002/jlcr.3365

CORC > 北京大学 > 化学与分子工程学院

	In vitro and in vivo evaluation of technetium-99m-labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers
	Zhang, Qiang ; Huang, Huafan ; Chu, Taiwei
刊名	JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
	2016
关键词	technetium-99m PnAO nitroimidazole nitrotriazole hypoxia TUMOR HYPOXIA BIOLOGICAL EVALUATION IMAGING HYPOXIA IODOAZOMYCIN ARABINOSIDE AGENT BISNITROIMIDAZOLE METRONIDAZOLE CANCER 2-NITROIMIDAZOLE OPPORTUNITIES
DOI	10.1002/jlcr.3365
英文摘要	Hypoxia markers have been the subject of intensive research in radiopharmaceuticals, but there is little work on markers with multi-redox centers. It is necessary to further develop and investigate the compounds containing multi-redox centers systematically. Two propylene amine oxime ligands, compound 1, containing 3-nitro-1,2,4-triazole and 4-nitroimidazole and compound 2, containing 3-nitro-1,2,4-triazole and 2-nitroimidazole were synthesized and radiolabeled with (99m) Tc; then these complexes were also evaluated in vitro and in vivo. Some comparisons were made with the other complexes of our previous work, and some interesting conclusions were obtained. Tc-99m-1 and Tc-99m-2 displayed significant hypoxic/normoxic differentials in both S180 and H22 cell lines. These complexes held moderate tumor-to-blood and tumor-to-muscle ratios, indicating they might serve as novel hypoxia markers. Some comparisons showed the in vitro evaluation may be connected with the number and the type of the redox centers, and the biodistribution experiments may have relation with the hydrophilicity and the type of redox centers.; National Science Foundation of China [21371017, 81371592]; SCI(E); PubMed; ARTICLE; twchu@pku.edu.cn; 1; 14-23; 59
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435768]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Qiang,Huang, Huafan,Chu, Taiwei. In vitro and in vivo evaluation of technetium-99m-labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,2016.
APA	Zhang, Qiang,Huang, Huafan,&Chu, Taiwei.(2016).In vitro and in vivo evaluation of technetium-99m-labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS.
MLA	Zhang, Qiang,et al."In vitro and in vivo evaluation of technetium-99m-labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2016).