Role of the ESAT-6 secretion system in virulence of the emerging   community-associated Staphylococcus aureus lineage ST398

doi:10.1038/srep25163

CORC > 北京大学 > 化学与分子工程学院

	Role of the ESAT-6 secretion system in virulence of the emerging community-associated Staphylococcus aureus lineage ST398
	Wang, Yanan ; Hu, Mo ; Liu, Qian ; Qin, Juanxiu ; Dai, Yingxin ; He, Lei ; Li, Tianming ; Zheng, Bing ; Zhou, Fan ; Yu, Kaiwen ; Fang, Jingyuan ; Liu, Xiaoyun ; Otto, Michael ; Li, Min
刊名	SCIENTIFIC REPORTS
	2016
关键词	METHICILLIN-RESISTANT INFECTIONS EPIDEMIOLOGY PATHOGENESIS PNEUMONIA PROTEINS
DOI	10.1038/srep25163
英文摘要	Novel Staphylococcus aureus clones continue to emerge that cause infections in otherwise healthy people. One example is the sequence type (ST) 398 lineage, which we show here is increasing in importance as a significant cause of community-associated (CA) human infections in China. We have a profound lack of understanding about what determines the considerable virulence potential of such newly emerging clones. Information about the contribution to virulence of the more recently discovered ESAT-6 secretion system (ESS) has remained particularly scarce. The Chinese ST398 isolates exhibited significantly increased expression of ESS genes as compared to predominant hospital-associated clones, which we found is likely due to increased expression of the accessory gene regulator (Agr) system and control of ESS by Agr. Importantly, deletion of essB in ST398 resulted in significantly reduced resistance to neutrophil killing and decreased virulence in murine skin and blood infection models. Our results demonstrate a key function of ESS in promoting virulence and mechanisms of resistance to innate host defense in an important emerging CA-S. aureus lineage. They suggest that ESS has a so far underestimated role in promoting aggressive virulence and epidemiological success of S. aureus.; Intramural Research Program of the National Institute of Allergy and Infectious Diseases; National Natural Science Foundation of China [81322025, 81421001, 81371875]; Shanghai Shuguang Talent Project [12SG03]; Shanghai Committee of Science and Technology, China [14140901000, 15411960500]; SCI(E); PubMed; ARTICLE; motto@niaid.nih.gov; ruth_limin@126.com; 25163; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433983]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Yanan,Hu, Mo,Liu, Qian,et al. Role of the ESAT-6 secretion system in virulence of the emerging community-associated Staphylococcus aureus lineage ST398[J]. SCIENTIFIC REPORTS,2016.
APA	Wang, Yanan.,Hu, Mo.,Liu, Qian.,Qin, Juanxiu.,Dai, Yingxin.,...&Li, Min.(2016).Role of the ESAT-6 secretion system in virulence of the emerging community-associated Staphylococcus aureus lineage ST398.SCIENTIFIC REPORTS.
MLA	Wang, Yanan,et al."Role of the ESAT-6 secretion system in virulence of the emerging community-associated Staphylococcus aureus lineage ST398".SCIENTIFIC REPORTS (2016).