Chemoproteomic profiling of protein modifications by lipid-derived   electrophiles

doi:10.1016/j.cbpa.2015.10.029

CORC > 北京大学 > 化学与分子工程学院

	Chemoproteomic profiling of protein modifications by lipid-derived electrophiles
	Chen, Ying ; Qin, Wei ; Wang, Chu
刊名	CURRENT OPINION IN CHEMICAL BIOLOGY
	2016
关键词	PEROXIDATION PRODUCTS 4-HYDROXYNONENAL PROTEIN OXIDATIVE STRESS LUNG-CANCER CROSS-LINKS ALPHA,BETA-UNSATURATED ALDEHYDES COVALENT MODIFICATION MASS-SPECTROMETRY CLICK CHEMISTRY LIVING CELLS
DOI	10.1016/j.cbpa.2015.10.029
英文摘要	Lipid-derived electrophiles (LDEs) are a group of endogenous reactive metabolites generated as products of lipid peroxidation when cells are under oxidative stress. LDEs are able to covalently modify nucleophilic residues in proteins to alter their structures and activities, either resulting in irreversible functional damage or triggering aberrant signaling pathways. Traditional biochemical methods have revealed individual protein targets modified by LDEs, however, deciphering the toxicity and/or signaling roles of LDEs requires systematic studies of these modifications in a high-throughput fashion. Here we survey recent progress in developing chemical proteomic strategies to globally profile protein-LDE interactions directly from complex proteomes. These powerful chemoproteomic methods have yielded a rich inventory of proteins and residue sites that are sensitive to LDE modification, serving as valuable resources to investigate mechanisms of their cellular toxicity at the molecular level.; National Natural Science Foundation of China [21472008, 81490740]; SCI(E); PubMed; REVIEW; chuwang@pku.edu.cn; 37-45; 30
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/424943]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Chen, Ying,Qin, Wei,Wang, Chu. Chemoproteomic profiling of protein modifications by lipid-derived electrophiles[J]. CURRENT OPINION IN CHEMICAL BIOLOGY,2016.
APA	Chen, Ying,Qin, Wei,&Wang, Chu.(2016).Chemoproteomic profiling of protein modifications by lipid-derived electrophiles.CURRENT OPINION IN CHEMICAL BIOLOGY.
MLA	Chen, Ying,et al."Chemoproteomic profiling of protein modifications by lipid-derived electrophiles".CURRENT OPINION IN CHEMICAL BIOLOGY (2016).