Complexation behavior of oppositely charged polyelectrolytes: Effect of   charge distribution

doi:10.1063/1.4921652

CORC > 北京大学 > 化学与分子工程学院

	Complexation behavior of oppositely charged polyelectrolytes: Effect of charge distribution
	Zhao, Mingtian ; Zhou, Jihan ; Su, Cuicui ; Niu, Lin ; Liang, Dehai ; Li, Baohui
刊名	JOURNAL OF CHEMICAL PHYSICS
	2015
关键词	ANGLE NEUTRON-SCATTERING GELATIN/POLYELECTROLYTE COMPLEXES DNA COMPACTION GENE DELIVERY PROTEIN POLYMERS DENSITY NANOPARTICLES RECOGNITION EFFICIENCY
DOI	10.1063/1.4921652
英文摘要	Complexation behavior of oppositely charged polyelectrolytes in a solution is investigated using a combination of computer simulations and experiments, focusing on the influence of polyelectrolyte charge distributions along the chains on the structure of the polyelectrolyte complexes. The simulations are performed using Monte Carlo with the replica-exchange algorithm for three model systems where each system is composed of a mixture of two types of oppositely charged model polyelectrolyte chains (EGEG)(5)/(KGKG)(5), (EEGG)(5)/(KKGG)(5), and (EEGG)(5)/(KGKG)(5), in a solution including explicit solvent molecules. Among the three model systems, only the charge distributions along the chains are not identical. Thermodynamic quantities are calculated as a function of temperature (or ionic strength), and the microscopic structures of complexes are examined. It is found that the three systems have different transition temperatures, and form complexes with different sizes, structures, and densities at a given temperature. Complex microscopic structures with an alternating arrangement of one monolayer of E/K monomers and one monolayer of G monomers, with one bilayer of E and K monomers and one bilayer of G monomers, and with a mixture of monolayer and bilayer of E/K monomers in a box shape and a trilayer of G monomers inside the box are obtained for the three mixture systems, respectively. The experiments are carried out for three systems where each is composed of a mixture of two types of oppositely charged peptide chains. Each peptide chain is composed of Lysine (K) and glycine (G) or glutamate (E) and G, in solution, and the chain length and amino acid sequences, and hence the charge distribution, are precisely controlled, and all of them are identical with those for the corresponding model chain. The complexation behavior and complex structures are characterized through laser light scattering and atomic force microscopy measurements. The order of the apparent weight-averaged molar mass and the order of density of complexes observed from the three experimental systems are qualitatively in agreement with those predicted from the simulations. (C) 2015 AIP Publishing LLC.; National Natural Science Foundation of China [20990232, 21174007, 20990234, 20925414, 91227121]; PCSIRT [IRT1257]; 111 Project; SCI(E); EI; PubMed; ARTICLE; dliang@pku.edu.cn; baohui@nankai.edu.cn; 20; 204902; 142
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419525]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhao, Mingtian,Zhou, Jihan,Su, Cuicui,et al. Complexation behavior of oppositely charged polyelectrolytes: Effect of charge distribution[J]. JOURNAL OF CHEMICAL PHYSICS,2015.
APA	Zhao, Mingtian,Zhou, Jihan,Su, Cuicui,Niu, Lin,Liang, Dehai,&Li, Baohui.(2015).Complexation behavior of oppositely charged polyelectrolytes: Effect of charge distribution.JOURNAL OF CHEMICAL PHYSICS.
MLA	Zhao, Mingtian,et al."Complexation behavior of oppositely charged polyelectrolytes: Effect of charge distribution".JOURNAL OF CHEMICAL PHYSICS (2015).