Deciphering the underlying mechanisms of Diesun Miaofang in traumatic   injury from a systems pharmacology perspective

doi:10.3892/mmr.2015.3638

CORC > 北京大学 > 化学与分子工程学院

	Deciphering the underlying mechanisms of Diesun Miaofang in traumatic injury from a systems pharmacology perspective
	Zheng, Chun-Song ; Fu, Chang-Long ; Pan, Cai-Bin ; Bao, Hong-Juan ; Chen, Xing-Qiang ; Ye, Hong-Zhi ; Ye, Jin-Xia ; Wu, Guang-Wen ; Li, Xi-Hai ; Xu, Hui-Feng ; Xu, Xiao-Jie ; Liu, Xian-Xiang
刊名	MOLECULAR MEDICINE REPORTS
	2015
关键词	traditional Chinese medicine Diesun Miaofang traumatic injury polypharmacology systems pharmacology TOUGU XIAOTONG GRANULE DRUG DISCOVERY COMPUTATIONAL PHARMACOLOGY OSTEOARTHRITIS RECEPTOR POLYPHARMACOLOGY VISUALIZATION COMPONENTS
DOI	10.3892/mmr.2015.3638
英文摘要	Diesun Miaofang (DSMF) is a traditional herbal formula, which has been reported to activate blood, remove stasis, promote qi circulation and relieve pain. DSMF holds a great promise for the treatment of traumatic injury in an integrative and holistic manner. However, its underlying mechanisms remain to be elucidated. In the present study, a systems pharmacology model, which integrated cluster ligands, human intestinal absorption and aqueous solution prediction, chemical space mapping, molecular docking and network pharmacology techniques were used. The compounds from DSMF were diverse in the clusters and chemical space. The majority of the compounds exhibited drug-like properties. A total of 59 compounds were identified to interact with 16 potential targets. In the herb-compound-target network, the majority of compounds acted on only one target; however, a small number of compounds acted on a large number of targets, up to a maximum of 12. The comparison of key topological properties in compound-target networks associated with the above efficacy intuitively demonstrated that potential active compounds possessed diverse functions. These results successfully explained the polypharmcological mechanism underlying the efficiency of DSMF for the treatment of traumatic injury as well as provided insight into potential novel therapeutic strategies for traumatic injury from herbal medicine.; Developmental Fund of ChenKeji Integrative Medicine [CKJ2010032]; SCI(E); ARTICLE; liuxianxiangfz@163.com; 2; 1769-1776; 12
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/417773]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zheng, Chun-Song,Fu, Chang-Long,Pan, Cai-Bin,et al. Deciphering the underlying mechanisms of Diesun Miaofang in traumatic injury from a systems pharmacology perspective[J]. MOLECULAR MEDICINE REPORTS,2015.
APA	Zheng, Chun-Song.,Fu, Chang-Long.,Pan, Cai-Bin.,Bao, Hong-Juan.,Chen, Xing-Qiang.,...&Liu, Xian-Xiang.(2015).Deciphering the underlying mechanisms of Diesun Miaofang in traumatic injury from a systems pharmacology perspective.MOLECULAR MEDICINE REPORTS.
MLA	Zheng, Chun-Song,et al."Deciphering the underlying mechanisms of Diesun Miaofang in traumatic injury from a systems pharmacology perspective".MOLECULAR MEDICINE REPORTS (2015).