Combined Photothermal and Surface-Enhanced Raman Spectroscopy Effect from Spiky Noble Metal Nanoparticles Wrapped within Graphene-Polymer Layers: Using Layer-by-layer Modified Reduced Graphene Oxide as Reactive Precursors | |
Li, Xiangming ; Zhang, Yihe ; Wu, Yaling ; Duan, Yang ; Luan, Xinglong ; Zhang, Qian ; An, Qi | |
刊名 | ACS APPLIED MATERIALS & INTERFACES |
2015 | |
关键词 | hybrid nanoparticles graphene gold nanoparticles photothermal surface-enhanced Raman scattering layer-by-layer DRUG SUPRAMOLECULAR HYDROGELS GOLD NANOPARTICLES IN-SITU BIOMEDICAL APPLICATIONS AU NANOPARTICLES FABRICATION SIZE NANOSTRUCTURES NANOHYBRIDS NANOSACKS |
DOI | 10.1021/acsami.5b05463 |
英文摘要 | To fabricate functionally integrated hybrid nanoparticles holds high importance in biomedical applications and is still a challenging task. In this study, we report the first reduced graphene oxide (rGO)-nobel metal hybrid particles that present simultaneously the photothermal and surface-enhanced Raman spectroscopy (SERS) effect from the inorganic part and drug loading, dispersibility, and controllability features from LbL polyelectrolyte multilayers. The hybrid particles where spiky noble metal particles were wrapped within rGO-polyelectrolyte layers were prepared by a facile and controllable method. rGO template modified using polyethylenimine (PEI) and poly(acrylic acid) (PAA) via layer-by-layer technology served as the reactive precursors, and the morphologies of the particles could be facilely controlled via controlling the number of bilayers around the rGO template. The hybrid particle presented low cytotoxicity. After loading doxorubicin hydrochloride, the particles effectively induced cell death, and photothermal treatment further decreased cell viability. rGO-Ag hybrid particles could be prepared similarly. We expect the reported method provides an effective strategy to prepare rGO-noble metal hybrid nanoparticles that find potential biomedical applications.; NSFC [21303169]; Fundamental Research Funds for the Central Universities [2652013115, 35532015002]; Beijing Nova Program [Z141103001814064]; Beijing Specific Project to Foster Elitist [2013D009015000001]; National High Technology Research and Development Program of China (863 Program) [2012AA06A109]; special coconstruction project of Beijing City Education; SCI(E); EI; PubMed; ARTICLE; zyh@cugb.edu.cn; wylleg@163.com; an@cugb.edu.cn; 34; 19353-19361; 7 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/416382] |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Li, Xiangming,Zhang, Yihe,Wu, Yaling,et al. Combined Photothermal and Surface-Enhanced Raman Spectroscopy Effect from Spiky Noble Metal Nanoparticles Wrapped within Graphene-Polymer Layers: Using Layer-by-layer Modified Reduced Graphene Oxide as Reactive Precursors[J]. ACS APPLIED MATERIALS & INTERFACES,2015. |
APA | Li, Xiangming.,Zhang, Yihe.,Wu, Yaling.,Duan, Yang.,Luan, Xinglong.,...&An, Qi.(2015).Combined Photothermal and Surface-Enhanced Raman Spectroscopy Effect from Spiky Noble Metal Nanoparticles Wrapped within Graphene-Polymer Layers: Using Layer-by-layer Modified Reduced Graphene Oxide as Reactive Precursors.ACS APPLIED MATERIALS & INTERFACES. |
MLA | Li, Xiangming,et al."Combined Photothermal and Surface-Enhanced Raman Spectroscopy Effect from Spiky Noble Metal Nanoparticles Wrapped within Graphene-Polymer Layers: Using Layer-by-layer Modified Reduced Graphene Oxide as Reactive Precursors".ACS APPLIED MATERIALS & INTERFACES (2015). |
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