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	Cytotoxicity of Zinc Oxide Nanoparticles: Importance of Microenvironment
	Yang, Sheng-Tao ; Liu, Jia-Hui ; Wang, Jing ; Yuan, Yuan ; Cao, Aoneng ; Wang, Haifang ; Liu, Yuanfang ; Zhao, Yuliang
	2010
关键词	Zinc Oxide Nanoparticles Cytotoxicity Solubility Microenvironment ZNO NANOPARTICLES NANOSTRUCTURED MATERIALS TOXICOLOGICAL IMPACT COMPARATIVE TOXICITY PARTICLE SOLUBILITY QUANTUM DOTS BULK ZNO CELLS BACTERIA NANOTECHNOLOGY
英文摘要	While ZnO particles are widely used in many fields, including personal care products, the high toxicity of ZnO nanoparticles has been reported and aroused great health concerns. In this study, the cytotoxicity of ZnO nanoparticles was evaluated and, in particular, the role of microenvironment in their toxicity was investigated. Our results show that ZnO nanoparticles are highly toxic to NIH/3T3 cells, inducing viability loss, membrane leakage and morphology changes. The microenviroment, here the CO(2) atmosphere under cell culture condition, promoted the solubilization of ZnO nanoparticles. Then the released Zn from ZnO nanoparticles induces the cytotoxicity. The importance of microenvironment on the ZnO nanotoxicity is presented and the implications to future nanotoxicology studies are discussed.; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter; SCI(E); EI; CPCI-S(ISTP); 27
语种	英语
DOI标识	10.1166/jnn.2010.2491
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/313180]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang, Sheng-Tao,Liu, Jia-Hui,Wang, Jing,et al. Cytotoxicity of Zinc Oxide Nanoparticles: Importance of Microenvironment. 2010-01-01.

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