Antibacterial Activity of Naphthyridone Derivatives Containing   8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds

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	Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds
	Feng, Lianshun ; Tan, Yanhong ; Wei, Zengquan ; Liu, Mingliang ; Guo, Huiyuan
刊名	asian journal of chemistry
	2014
关键词	Naphthyridone derivatives 8-Alkoxyimino-1,6-dizaspiro[3.4]octane Scaffolds Antibacterial activity
英文摘要	We report herein in vitro antibacterial activity of a series of novel naphthyridone derivatives containing 8-alkoxyimino-1,6-dizaspiro[ 3.4] octane scaffolds, the position isomers of the side chain at the C-7 position of zabofloxacin. Our results revealed that the target compounds were generally less active than the reference against the tested Gram-positive and Gram-negative strains with few exceptions, but compounds 1-5 and 7 showed good activity against MSSA and P. aeruginosa (MICs: 0.25-1 mu g/mL). Especially, compounds 3 and 7 (MICs: 0.25 mu g/mL) were found to be 4 times more potent than or comparable to levofloxacin against P. aeruginosa, the important conditioned pathogen on hospital infection. Simple structure-activity relationship was also discussed in this paper.; Chemistry, Multidisciplinary; SCI(E); 0; ARTICLE; lmllyx@126.com; 13; 3805-3807; 26
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/313078]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Feng, Lianshun,Tan, Yanhong,Wei, Zengquan,et al. Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds[J]. asian journal of chemistry,2014.
APA	Feng, Lianshun,Tan, Yanhong,Wei, Zengquan,Liu, Mingliang,&Guo, Huiyuan.(2014).Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds.asian journal of chemistry.
MLA	Feng, Lianshun,et al."Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds".asian journal of chemistry (2014).