Biodistribution and tumor uptake of C-60(OH)(x) in mice

doi:10.1007/s11051-005-9001-5

CORC > 北京大学 > 化学与分子工程学院

	Biodistribution and tumor uptake of C-60(OH)(x) in mice
	Ji, ZQ ; Sun, HF ; Wang, HF ; Xie, QY ; Liu, YF ; Wang, Z
刊名	journal of nanoparticle research
	2006
关键词	biodistribution fullerol medicine photodynamic therapy (PDT) radioiodination tumor-bearing mice FULLERENE DERIVATIVES C-60 MECHANISM ACID
DOI	10.1007/s11051-005-9001-5
英文摘要	Radiolabeling of fullerol, I-125-C-60(OH) (x) , was performed by the traditional chloramine-T method. The C-I covalent bond in I-C-60(OH) (x) was characterized by X-ray photoelectron spectroscopy (XPS) that was sufficiently stable for in vivo study. Laser light scattering spectroscopy clearly showed that C-60(OH) (x) aggregated to large nanoparticle clumps with a wide range of distribution. The clumps formed were also visualized by transmission electron microscope (TEM). We examined the biodistribution and tumor uptake of C-60(OH) (x) in five mouse bearing tumor models, including mouse H22 hepatocarcinoma, human lung giantcellcarcinoma PD, human colon cancer HCT-8, human gastric cancer MGC803, and human OS732 osteosarcoma. The accumulation ratios of I-125-C-60(OH) (x) in mouse H22 hepatocarcinoma to that in normal muscle tissue (T/N) and blood (T/B) at 1, 6, 24 and 72 h, reveal that I-125-C-60(OH) (x) gradually accumulates in H22 tumor, and retains for a quite long period (e.g., T/N 3.41, T/B 3.94 at 24 h). For the other four tumor models, the T/N ratio at 24 h ranges within 1.21-6.26, while the T/B ratio ranges between 1.23 and 4.73. The accumulation of C-60(OH) (x) in tumor is mostly due to the enhanced permeability and retention effect (EPR) and the phagocytosis of mononuclear phagocytes. Hence, C-60(OH) (x) might serve as a photosensitizer in the photodynamic therapy of some kinds of tumor.; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; SCI(E); EI; 0; ARTICLE; 1; 53-63; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/252339]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Ji, ZQ,Sun, HF,Wang, HF,et al. Biodistribution and tumor uptake of C-60(OH)(x) in mice[J]. journal of nanoparticle research,2006.
APA	Ji, ZQ,Sun, HF,Wang, HF,Xie, QY,Liu, YF,&Wang, Z.(2006).Biodistribution and tumor uptake of C-60(OH)(x) in mice.journal of nanoparticle research.
MLA	Ji, ZQ,et al."Biodistribution and tumor uptake of C-60(OH)(x) in mice".journal of nanoparticle research (2006).