含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体

doi:10.3321/j.issn:1000-3304.2009.01.016

CORC > 北京大学 > 化学与分子工程学院

	含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体; ACID SENSITIVE MICELLAR AGGREGATES BASED ON AMPHIPHILIC BLOCK COPOLYMERS WITH PENDANT CYCLIC ORTHOESTER
	黄潇楠 ; 杜福胜 ; 杨俊 ; 李子臣
刊名	高分子学报
	2009
关键词	原酸酯聚乙二醇嵌段共聚物酸敏感胶束状聚集体 Orthoester PEO Block copolymer Acid-sensitive Micellar aggregate
DOI	10.3321/j.issn:1000-3304.2009.01.016
英文摘要	合成了含有环状原酸酯基团的单体,甲基丙烯酸5-(5-甲基-2-乙氧基-1,3-二氧六环)甲酯(EDMM),以PEO大分子引发剂引发,通过原子转移自由基聚合方法制备了两个疏水链段(PEDMM)长度不同的酸敏感两亲性嵌段共聚物,PEO-b-PEDMM17和PEO-b-PEDMM34.两个聚合物在水溶液中形成粒径约为60～200 nm的球型聚集体,通过动态光散射、透射电镜、荧光探针等手段表征了所得聚集体.结果显示,疏水链段较短的共聚物的临界聚集浓度较高,形成的聚集体尺寸较小.核磁和荧光探针结果表明,胶束状聚集体在中性(pH 7.4)水溶液中比较稳定,在酸性水溶液中其疏水核的极性因原酸酯的水解而增加.该类酸敏感胶束状聚集体有望用于肿瘤、细胞内给药等药物传递体系.; Acid-sensitive polymeric micelles have great potential as carriers for target drug delivery systems. In this work, a methacrylate monomer with cyclic orthoester group, (2-ethoxy-5-methyl-1, 3-dioxan-5-yl)methyl methacrylate (EDMM), was synthesized. Two acid-sensitive amphiphilic block copolymers, PEO-b-PEDMM(17) and PEO-b-PEDMM(34), were prepared by the atom transfer radical polymerization of EDMM using a PEO macroinitiator (molecular weight ca. 2000 Da). The compositions and molecular weights of the two block copolymers were measured by using (1)H-NMR and GPC, respectively. Both polymers are not water soluble due to the hydrophobicity of PEDMM segments. However, micellar aggregates with sizes of 60 similar to 200 nm were obtained by slowly adding excessive phosphate buffer (10 mmol/L, pH 7.4) to the polymer solutions in tetrahydrofuran (THF) and then evaporating THF. The micellar aggregates were characterized by dynamic light scattering, transmission electronic microscopy and Nile lied fluorescence probe. PEO-b-PEDMM(17), the polymer with a shorter hydrophobic chain length, had a lower critical aggregation concentration (cac) and formed micellar aggregates with smaller size compared with PEO-b-PEDMM(34), pH-Dependent hydrolysis of the aggregates were monitored by Nile Red (Nil) probe and (1)H-NMR approaches, showing that the polymer aggregates were stable at pH 7.4, but the polarity of the micellar core increased with time at pH 5.0 due to the acid-triggered hydrolysis of the orthoester groups. This type of acid sensitive micellar aggregates may find applications as carriers for tumor tissue and/or intracellular drug delivery.; 国家自然科学基金; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000263728600016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 2; 1; 88-92
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/246591]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	黄潇楠,杜福胜,杨俊,等. 含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体, ACID SENSITIVE MICELLAR AGGREGATES BASED ON AMPHIPHILIC BLOCK COPOLYMERS WITH PENDANT CYCLIC ORTHOESTER[J]. 高分子学报,2009.
APA	黄潇楠,杜福胜,杨俊,&李子臣.(2009).含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体.高分子学报.
MLA	黄潇楠,et al."含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体".高分子学报 (2009).