Fabrication, Mechanical Properties, and Biocompatibility of   Graphene-Reinforced Chitosan Composites

doi:10.1021/bm100470q

CORC > 北京大学 > 化学与分子工程学院

	Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan Composites
	Fan, Hailong ; Wang, Lili ; Zhao, Keke ; Li, Nan ; Shi, Zujin ; Ge, Zigang ; Jin, Zhaoxia
刊名	biomacromolecules
	2010
关键词	WALLED CARBON NANOTUBES GRAPHITE OXIDE ELECTRICAL-CONDUCTIVITY AQUEOUS DISPERSIONS METAL IMPURITIES NANOCOMPOSITES SCAFFOLDS SHEETS TEMPERATURE DERIVATIVES
DOI	10.1021/bm100470q
英文摘要	Few-layered graphene sheets, synthesized by direct current arc-discharge method using NH(3) as one of the buffer gases, were dispersed in chitosan/acetic acid solutions. FTIR and X-ray photoelectron spectroscopy showed the presence of oxygen-containing functional groups on the surface of graphene sheets that may assist the good dispersion of graphene in chitosan solution. Graphene/chitosan films were produced by solution casting method. The mechanical properties of composite films were tested by nanoindentation method. With the addition of a small amount of graphene in chitosan (0.1-0.3 wt %), the elastic modulus of chitosan increased over similar to 200%. The biocompatibility of graphene/chitosan composite films was checked by tetrazolium-based colorimetric assays in vitro. The cell adhesion result showed that the L929 cell can adhere to and develop on the graphene/chitosan composite films as well as on pure chitosan film, indicating that graphene/chitosan composites have good biocompatibility. Because there is no metallic impurity in graphene raw materials, the time-consuming purification process for removing metal nanoparticles entrapped in carbon nanotubes is thus avoided when graphene is used to prepare biomedical materials. Graphene/chitosan composites are potential candidates as scaffold materials in tissue engineering.; Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science; SCI(E); EI; 144; ARTICLE; 9; 2345-2351; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/243282]
专题	化学与分子工程学院工学院
推荐引用方式 GB/T 7714	Fan, Hailong,Wang, Lili,Zhao, Keke,et al. Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan Composites[J]. biomacromolecules,2010.
APA	Fan, Hailong.,Wang, Lili.,Zhao, Keke.,Li, Nan.,Shi, Zujin.,...&Jin, Zhaoxia.(2010).Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan Composites.biomacromolecules.
MLA	Fan, Hailong,et al."Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan Composites".biomacromolecules (2010).