ESI Mass Spectrometric Exploration of Selective Recognition of   G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic   Polyamide

doi:10.1007/s13361-013-0802-y

CORC > 北京大学 > 化学与分子工程学院

	ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide
	Cui, Xiaojie ; Zhang, Qiang ; Chen, Han ; Zhou, Jiang ; Yuan, Gu
刊名	journal of the american society for mass spectrometry
	2014
关键词	G-quadruplex C-myb Selective binding Cyclic polyamide ESI-MS TRIPLET REPEAT DNA HUMAN INSULIN GENE PARALLEL QUADRUPLEXES TELOMERIC DNA KIT PROMOTER REGION EXPRESSION DIFFERENTIATION THERAPEUTICS CONVERSION
DOI	10.1007/s13361-013-0802-y
英文摘要	In this research, electrospray ionization mass spectrometry (ESI-MS) was used to probe the binding selectivity of a flexible cyclic polyamide (c beta) to G-quadruplexes from the long G-rich sequences in the c-myb oncogene promoter. The results show that three G-rich sequences, including d[(GGA)(3)GGTCAC(GGA)(4)], d[(GGA)(4)GAA(GGA)(4)], and d[(GGA)(3)GGTCAC(GGA)(4)GAA(GGA)(4)] species in the c-myb promoter can form parallel G-quadruplexes, and c beta selectively binds towards these G-quadruplexes over both several other G-quadruplexes and the duplex DNA. These properties of c beta have profound implications on future studies of the regulation of c-myb oncogene expression.; Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical; Spectroscopy; SCI(E); EI; 3; ARTICLE; guyuan@pku.edu.cn; 4; 684-691; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/215567]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Cui, Xiaojie,Zhang, Qiang,Chen, Han,et al. ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide[J]. journal of the american society for mass spectrometry,2014.
APA	Cui, Xiaojie,Zhang, Qiang,Chen, Han,Zhou, Jiang,&Yuan, Gu.(2014).ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide.journal of the american society for mass spectrometry.
MLA	Cui, Xiaojie,et al."ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide".journal of the american society for mass spectrometry (2014).