A computationally designed Rh(I)-catalyzed two-component [5+2+1]   cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of   cyclooctenones

doi:10.1021/ja072505w

CORC > 北京大学 > 化学与分子工程学院

	A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones
	Wang, Yuanyuan ; Wang, Jingxin ; Su, Jiachun ; Huang, Feng ; Jiao, Lei ; Liang, Yong ; Yang, Dazhi ; Zhang, Shiwei ; Wender, Paul A. ; Yu, Zhi-Xiang
刊名	journal of the american chemical society
	2007
关键词	8-MEMBERED RINGS 3-COMPONENT CYCLOADDITIONS ALKYNES CONSTRUCTION POLYACETYLENE ELIMINATION METATHESIS COMPLEXES CATALYSTS ALKENES
DOI	10.1021/ja072505w
英文摘要	Through the combined use of computational (density functional theory) and experimental studies, a new [Rh(CO)(2)Cl](2) catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of fused bicyclic cyclooctenones has been designed and experimentally realized. The key point behind this design is to turn a disfavored reductive elimination of (sp(3))C-Rh-C(sp(3)) to an easier migratory reductive elimination of (sp(3))C-Rh-CO-C(sp(3)) by the introduction of CO. These reactions proceed in good yields for substrates with various tether types and substituents, providing a flexible, convenient, efficient, and stereocontrolled method for the construction of bicyclic cyclooctenones.; Chemistry, Multidisciplinary; SCI(E); EI; PubMed; 78; ARTICLE; 33; 10060-+; 129
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/198003]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wang, Yuanyuan,Wang, Jingxin,Su, Jiachun,et al. A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones[J]. journal of the american chemical society,2007.
APA	Wang, Yuanyuan.,Wang, Jingxin.,Su, Jiachun.,Huang, Feng.,Jiao, Lei.,...&Yu, Zhi-Xiang.(2007).A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones.journal of the american chemical society.
MLA	Wang, Yuanyuan,et al."A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclooctenones".journal of the american chemical society (2007).