Multistep DNA-Templated Synthesis Using a Universal Template

doi:10.1021/ja409936r

CORC > 北京大学 > 化学与分子工程学院

	Multistep DNA-Templated Synthesis Using a Universal Template
	Li, Yizhou ; Zhao, Peng ; Zhang, Mingda ; Zhao, Xianyuan ; Li, Xiaoyu
刊名	journal of the american chemical society
	2013
关键词	ENCODED CHEMICAL LIBRARIES IN-VITRO SELECTION ORGANIC-SYNTHESIS DESIGN INHIBITORS DISCOVERY VERSATILE MACROCYCLES MOLECULES SEQUENCE
DOI	10.1021/ja409936r
英文摘要	We report a DNA-templated synthesis method that allows construction of the entire DNA-encoded library with a single DNA template. Taking advantage of deoxyinosine's indiscriminate base-pairing property, we designed a "universal template" that is capable of directing chemical reactions with multiple reactant DNAs with different sequences. In combination with other design features including photocleavable linkers and direct encoding by the reactant DNA, we demonstrated the capabilities of the universal template in library synthesis, target selection, and hit decoding. Our method can be generally and straightforwardly applied to prepare a variety of chemically diverse DNA-encoded libraries.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328099400019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; SCI(E); 17; ARTICLE; 47; 17727-17730; 135
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150696]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Li, Yizhou,Zhao, Peng,Zhang, Mingda,et al. Multistep DNA-Templated Synthesis Using a Universal Template[J]. journal of the american chemical society,2013.
APA	Li, Yizhou,Zhao, Peng,Zhang, Mingda,Zhao, Xianyuan,&Li, Xiaoyu.(2013).Multistep DNA-Templated Synthesis Using a Universal Template.journal of the american chemical society.
MLA	Li, Yizhou,et al."Multistep DNA-Templated Synthesis Using a Universal Template".journal of the american chemical society (2013).