Au@Pt nanostructures: a novel photothermal conversion agent for cancer   therapy

doi:10.1039/c3nr06841b

CORC > 北京大学 > 化学与分子工程学院

	Au@Pt nanostructures: a novel photothermal conversion agent for cancer therapy
	Tang, Jinglong ; Jiang, Xiumei ; Wang, Liming ; Zhang, Hui ; Hu, Zhijian ; Liu, Ying ; Wu, Xiaochun ; Chen, Chunying
刊名	nanoscale
	2014
关键词	GOLD NANORODS CELLULAR UPTAKE DRUG-DELIVERY ASPECT RATIO NANOPARTICLES PEROXIDASE EFFICIENCY OXIDASE GROWTH CELLS
DOI	10.1039/c3nr06841b
英文摘要	Due to aspect ratio dependent localized surface plasmon resonance (SPR), gold nanorods (Au NRs) can be tuned to have a strong absorption in the near infrared region (NIR) and convert light to heat energy, which shows promises in cancer photothermal therapy. In this study, we introduced another more efficient NIR photothermal agent, Au nanorods coated with a shell of Pt nanodots (Au@Pt nanostructures). After surface modification with Pt dots, the Au@Pt nanostructure became a more efficient photothermal therapy agent as verified both in vitro and in vivo. To clarify the mechanism, we assessed the interaction between the MDA-MB-231 cells with Au@Pt or Au NRs. Results showed that the slightly higher uptake and the reduced sensitivity of the longitudinal SPR band on the intracellular aggregate state may contribute to the better photothermal efficiency for Au@Pt NRs. The theoretical studies further confirmed that the Au@Pt nanostructure itself exhibited better photothermal efficiency compared to Au NRs. These advantages make the Au@Pt nanostructure a more attractive and effective agent for cancer photothermal therapy than general Au NRs.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333042500033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; SCI(E); EI; 10; ARTICLE; wuxc@nanoctr.cn; chenchy@nanoctr.cn; 7; 3670-3678; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150648]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Tang, Jinglong,Jiang, Xiumei,Wang, Liming,et al. Au@Pt nanostructures: a novel photothermal conversion agent for cancer therapy[J]. nanoscale,2014.
APA	Tang, Jinglong.,Jiang, Xiumei.,Wang, Liming.,Zhang, Hui.,Hu, Zhijian.,...&Chen, Chunying.(2014).Au@Pt nanostructures: a novel photothermal conversion agent for cancer therapy.nanoscale.
MLA	Tang, Jinglong,et al."Au@Pt nanostructures: a novel photothermal conversion agent for cancer therapy".nanoscale (2014).