Study on chiral resolution of three beta-blockers by affinity   electrokinetic chromatography

doi:10.1016/j.talanta.2007.11.007

CORC > 北京大学 > 化学与分子工程学院

	Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography
	Yang, Guoqiang ; Zhao, Yifang ; Li, Mewan ; Zhu, Zhiwei ; Zhuang, Qiankun
刊名	talanta
	2008
关键词	beta-blockers chiral resolution bovine serum albumin affinity electrokinetic chromatography PERFORMANCE LIQUID-CHROMATOGRAPHY HUMAN SERUM-ALBUMIN CAPILLARY-ELECTROPHORESIS ENANTIOMERIC SEPARATION MASS-SPECTROMETRY STATIONARY PHASES PROPRANOLOL METABOLITES IONIZATION SELECTORS
DOI	10.1016/j.talanta.2007.11.007
英文摘要	The chiral resolution of three beta-blockers including propranolol, pindolol and oxprenolol, was studied by affinity electrokinetic chromatography. The effect of various chiral selectors and some key parameters including buffer pH, buffer concentration, capillary temperature and applied voltage were carefully studied, respectively. At optimum condition, based on the signal-to-noise ratio of 3, the detection limits for the simple resolution and chiral resolution were found to be 1.0 x 10(-5) and 4.0 x 10(-5) M, respectively. In addition, the interactions of these beta-blockers with bovine serum albumin (BSA) were studied and the binding constant (K-a) between BSA and each of beta-blockers were calculated. Based on linear correlation coefficient, it can be concluded that the binding ratio of pindolol (oxprenolol) combining with BSA is 1:1, and that the binding number of propranolol interacting with BSA deviates one. (C) 2007 Elsevier B.V. All rights reserved.; Chemistry, Analytical; SCI(E); EI; PubMed; 10; ARTICLE; 1; 222-226; 75
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150238]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang, Guoqiang,Zhao, Yifang,Li, Mewan,et al. Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography[J]. talanta,2008.
APA	Yang, Guoqiang,Zhao, Yifang,Li, Mewan,Zhu, Zhiwei,&Zhuang, Qiankun.(2008).Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography.talanta.
MLA	Yang, Guoqiang,et al."Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography".talanta (2008).