Multi-responsive nanogels containing motifs of ortho ester,   oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic   anti-cancer drugs

doi:10.1016/j.jconrel.2011.02.029

CORC > 北京大学 > 化学与分子工程学院

	Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs
	Qiao, Zeng-Ying ; Zhang, Rui ; Du, Fu-Sheng ; Liang, De-Hai ; Li, Zi-Chen
刊名	journal of controlled release
	2011
关键词	Nanogel Acid-labile Thermoresponsive Reduction-sensitive Ortho ester Oligo(ethylene glycol) CROSS-LINKED MICELLES CORE-SHELL MICROGELS POLYMERIC MICELLES HYDROGEL NANOPARTICLES INTRACELLULAR DELIVERY N-ISOPROPYLACRYLAMIDE POLY(ETHYLENE OXIDE) PACLITAXEL DELIVERY BLOCK-COPOLYMERS GEL PARTICLES
DOI	10.1016/j.jconrel.2011.02.029
英文摘要	A family of multi-responsive nanogels with different compositions and crosslinking degrees have been prepared by the miniemulsion copolymerization of monomethyl oligo(ethylene glycol) acrylate (OEGA) and an ortho ester-containing acrylic monomer, 2-(5,5-dimethyl-1,3-dioxan-2-yloxy) ethyl acrylate (DMDEA), with bis(2-acryloyloxyethyl) disulfide (BADS) as a crosslinker. These nanogels are thermoresponsive and labile in the weakly acidic or reductive environments. The thermoresponsive behaviors, acid-triggered hydrolysis, and reduction-induced degradation of these nanogels were studied by means of dynamic light scattering (DLS), transmission electron microscopy (TEM) and atomic force microscopy (AFM). The results indicate that the volume phase transition temperature (VPTT), thermally induced deswelling ratio, and acid-triggered swelling ratio of the nanogels are closely relevant to their compositions and crosslinking degrees. Although these nanogels could be reductively disrupted by dithiothreitol (DTT), single polymer chains with sizes smaller than 20 nm were not detected by DLS. This is probably due to the existence of some unbreakable linkages formed by chain transfer to the disulfide bond during the radical polymerization. These nanogels are capable of encapsulating hydrophobic compounds. The loading capability of the nanogels for Nile Red (NR), paclitaxel (PTX). and doxorubicin (DOX), and the release behaviors of the drug-loaded nanogels were investigated by UV-vis spectrometry and HPLC. As expected, drug release can be greatly accelerated by a cooperative effect of both acid-triggered hydrolysis and DTT-induced degradation. Finally, the PTX-loaded nanogels exhibit a concentration-dependent toxicity to MCF-7 cells while the intact unloaded nanogels are non-toxic, thereby they may be used as potential carriers for hydrophobic anticancer drugs. (C) 2011 Elsevier B.V. All rights reserved.; Chemistry, Multidisciplinary; Pharmacology & Pharmacy; SCI(E); EI; PubMed; 56; ARTICLE; 1,SI; 57-66; 152
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150022]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Qiao, Zeng-Ying,Zhang, Rui,Du, Fu-Sheng,et al. Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs[J]. journal of controlled release,2011.
APA	Qiao, Zeng-Ying,Zhang, Rui,Du, Fu-Sheng,Liang, De-Hai,&Li, Zi-Chen.(2011).Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs.journal of controlled release.
MLA	Qiao, Zeng-Ying,et al."Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs".journal of controlled release (2011).