Three-dimensional domain swapping in the protein structure space

doi:10.1002/prot.24055

CORC > 北京大学 > 化学与分子工程学院

	Three-dimensional domain swapping in the protein structure space
	Huang, Yongqi ; Cao, Huaiqing ; Liu, Zhirong
刊名	proteins structure function and bioinformatics
	2012
关键词	domain swapping dataset SCOP protein-protein interaction hinge loop interface RIBONUCLEASE-A CRYSTAL-STRUCTURE PROLINE RESIDUES HISTONE FOLD 3D MECHANISM DESIGN DIMER DETERMINANTS SEQUENCE
DOI	10.1002/prot.24055
英文摘要	Since the proposal of three-dimensional (3D) domain swapping, many 3D domain-swapped structures have been reported. However, when compared with the vast protein structure space, it is still unclear whether 3D domain swapping is a general mechanism for protein assembly. Here, we investigated this possibility by constructing a dataset consisting of more than 500 domain-swapped structures. The domain-swapped structures were mapped into the protein structure space. We found that about 10% of protein folds and 5% of protein families contain domain-swapped structures. When comparing the domain-swapped structures in a family/superfamily, we found that proteins within a family/superfamily can swap in different ways. Interface analysis revealed that the hinge loops contributed more than half of the open interface in 70% of bona fide domain-swapped dimers, indicating that the hinge loops play an important role in stabilizing the domain-swapped conformations. Our study supports the suggestion that domain swapping is a general property of all proteins and will facilitate further understanding the mechanism of 3D domain swapping. Proteins 2012. (c) 2012 Wiley Periodicals, Inc.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000303759000008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Biophysics; SCI(E); PubMed; 19; ARTICLE; 6; 1610-1619; 80
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149906]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Huang, Yongqi,Cao, Huaiqing,Liu, Zhirong. Three-dimensional domain swapping in the protein structure space[J]. proteins structure function and bioinformatics,2012.
APA	Huang, Yongqi,Cao, Huaiqing,&Liu, Zhirong.(2012).Three-dimensional domain swapping in the protein structure space.proteins structure function and bioinformatics.
MLA	Huang, Yongqi,et al."Three-dimensional domain swapping in the protein structure space".proteins structure function and bioinformatics (2012).