| 解吸电喷雾电离技术; Desorption Electrospray Ionization | |
| 薛震 ; 邱波 ; 林广欣 ; 赖丛芳 ; 罗海 | |
| 2008 | |
| 关键词 | 解吸电喷雾电离 常压离子化 电离源 表面分析 检测技术 desorption electrospray ionization (DESI) ambient ionization ion source surface analysis detection technique |
| 英文摘要 | 本文介绍了一种新近发展起来的质谱离子化方法--解吸电喷雾电离(desorption electrosprayionization,DESI)及其最新研究进展.该方法首次于2004年提出,由于其具有样品无需前处理就可以在常压条件下从各种载物表面直接分析固相或凝固相样品等优势而得到了迅速的发展.本文描述了DESI的基本原理、离子源的结构和相关优化的参数,并对该离子化方法中所用的载物表面进行了总结.在实际应用方面,本文综述了DESI技术在常压气相化学反应产物监测、合成高聚物表征、爆炸物和化学战毒剂检测,以及在药品、生物代谢产物和生物组织表面分析方面的应用成果,同时对DESI的基础应用研究方向进行了分析和展望.; Desorption electrospray ionization (DESI), a new ionization method of mass spectrometry, and its most recent research advances are reviewed. This method was first introduced in 2004 and developed very rapidly because of its advanced analytical characteristics, such as ambient working conditions, needn't sample preparation, and capable of directly analyzing solid or condensed form of samples from a variety of substrate surfaces. The recent comprehensive studies of DESI are reviewed in several aspects, including its basic principle, ion source structure, the optimal operational parameters and the substrate surfaces used in the ionization process. This article also summarized applications of DESI technique in monitoring ambient gas-phase chemical reaction products, characterizing synthetic polymers, detecting explosives and chemical warfare agents, analyzing drugs and metabolites, and profiling biological tissue surfaces. Meanwhile, the future directions of fundamental and applied research using DESI technique are commented.; 国家自然科学基金; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000255239400019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 8; 4; 594-601; 20 |
| 语种 | 中文 |
| 出处 | SCI ; 万方 ; http://d.g.wanfangdata.com.cn/Periodical_hxjz200804019.aspx |
| 出版者 | 化学进展 |
| 内容类型 | 其他 |
| 源URL | [http://hdl.handle.net/20.500.11897/80380]  |
| 专题 | 化学与分子工程学院 |
| 推荐引用方式 GB/T 7714 | 薛震,邱波,林广欣,等. 解吸电喷雾电离技术, Desorption Electrospray Ionization. 2008-01-01. |
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