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	中红外光纤技术用于口腔肿瘤在体原位检测的研究; In vivo and rapid detection of the malignancy tumor of oral tissues using Mid-FTIR fiber optics spectroscopy
	徐怡庄 ; 张元福 ; 杨丽敏 ; 彭歆 ; 孙开华 ; 李庆波 ; 周维金 ; 武惠中 ; 俞光岩 ; 刘智 ; 翁诗甫 ; 王晶 ; 赵莹 ; 徐端夫 ; 吴瑾光
	2004
关键词	中红外光纤 口腔肿瘤 在体原位检测 FTIR Mid-IR fiber optics FTIR malignancy tumor of oral tissue in vivo and in situ detection
英文摘要	Our previous studies show that mid-FTIR spectroscopy can be used to distinguish malignant oral tissue from normal tissue under in vitro condition. Here, an in-situ FTIR spectroscopic measurement was performed to record FTIR spectra of normal and malignant oral tissues including salivary gland, tongu...; Our previous studies show that mid-FTIR spectroscopy can be used to distinguish malignant oral tissue from normal tissue under in vitro condition. Here, an in-situ FTIR spectroscopic measurement was performed to record FTIR spectra of normal and malignant oral tissues including salivary gland, tongue, parotid gland, submandibular gland etc. during clinical examination. The FTIR spectra of various oral tissues were acquired when an ATR probe linked to the FTIR. spectrometer via mid-IR optical fibers was pressed on the tissues of the patients. For example, a patient(male, 76 years old) with tumor on the left parotid and the corresponding normal tissue on the right parotid were measured and obvious differences were observed. The spectral features of normal tissue and tumor are in good agreement with the criteria established in our previous work. (1) 1389 cm(-1) band is quite strong in tumor, while the corresponding band in normal tissue is weaker than 1452 cm(-1) band. (2) In normal tissue, 1250 cm(-1) band is stronger, but the 1250 cm(-1) band disappeared in the skin. of malignant tissue. The above results demonstrate that in vivo FTIR spectra are in good agreement with our previous results obtained under in vitro condition. We believe that in vivo FTIR spectroscopy, providing the first-hand information concerning whether the suspected tissue is cancerous or not, is helpful for doctors in clinical activity.; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 11; 02; 348-350; 25
语种	中文
出处	SCI ; 万方 ; 知网
出版者	高等学校化学学报
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/80315]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	徐怡庄,张元福,杨丽敏,等. 中红外光纤技术用于口腔肿瘤在体原位检测的研究, In vivo and rapid detection of the malignancy tumor of oral tissues using Mid-FTIR fiber optics spectroscopy. 2004-01-01.

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