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	利用网络药理学方法研究热毒宁注射液抗流感病毒的分子作用机制; Study on Mechanism of the Reduning Injection on the Influenza Virus Using Network Pharmacology Method
	张新庄 ; 萧伟 ; 徐筱杰 ; 王振中 ; 曹亮 ; 孙兰
	2013
关键词	网络药理学 热毒宁 流感病毒 中药 神经氨酸酶 Network pharmacology Reduning Influenza virus Traditional Chinese medicine Neuraminidase
英文摘要	采用分子对接、网络分析预测热毒宁注射液抗流感病毒的分子作用机制,并通过已建立的体外流感病毒神经氨酸酶筛选模型对网络预测结果验证.结果表明,热毒宁注射液所含化合物在化学空间上具有类药性质;网络分析揭示出热毒宁注射液是通过与流感病毒吸附、脱壳、复制以及释放等环节的多个蛋白相互作用发挥抗流感病毒作用的;对于预测的15个活性分子而言,实验结果初步证实,对A型流感病毒,木犀草素呈现较强的抑制作用,槲皮素则呈现较弱的抑制作用,这也初步证实了预测结果.; The mechanisms of the Reduning injection on the influenza virus were studied by computer methods at the molecular level, including docking and network analysis. A neuraminidase (NA) activity assay was used to verify the predicted results in vitro. Results show that most of the compounds in the Reduning injection exhibit good drug-like properties. The mechanism of the Reduning injection may be that it affects viral entry, RNA synthesis, or viral release, which limits influenza virus replication. Potential active molecules of the Reduning injection were found by analyzing the network parameters of compound-target interaction networks. The experimental results suggest that of the potential active molecules, luteolin displayed significant inhibitory activity toward the influenza A virus, while quercetin proved less effective, which supports the predicted results.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000320439300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); 中文核心期刊要目总览(PKU); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 5; 07; 1415-1420; 29
语种	中文
出处	知网 ; 万方 ; SCI
出版者	物理化学学报
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/10151]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	张新庄,萧伟,徐筱杰,等. 利用网络药理学方法研究热毒宁注射液抗流感病毒的分子作用机制, Study on Mechanism of the Reduning Injection on the Influenza Virus Using Network Pharmacology Method. 2013-01-01.

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