QQ客服 官方微博 反馈留言

	Early goal-directed nutrition in ICU patients (EAT-ICU): protocol for a randomised trial
	Allingstrup, Matilde Jo ; Kondrup, Jens ; Wiis, Jorgen ; Claudius, Casper ; Pedersen, Ulf Gottrup ; Hein-Rasmussen, Rikke ; Jensen, Tom Hartvig ; Lange, Theis ; Perner, Anders
	2016
关键词	CRITICALLY-ILL PATIENTS PARENTERAL-NUTRITION ENERGY NUTRITION PROTEIN SEPSIS PROVISION
英文摘要	INTRODUCTION: Extensive weight loss has been documented in intensive care unit (ICU) survivors, primarily as the result of muscle loss, leading to impaired physical function and reduced quality of life. The aim of the EAT-ICU trial is to test the effect of early goal-directed protein-energy nutrition based on measured requirements on short-term clinical outcomes and long-term physical quality of life in ICU patients. METHODS: The EAT-ICU trial is a single-centre, randomised, parallel-group trial with concealed allocation and blinded outcome assessment. A total of 200 consecutive, acutely admitted, mechanically ventilated intensive care patients will be randomised 1: 1 to early goal-directed nutrition versus standard of care to show a potential 15% relative risk reduction in the primary outcome measure (physical function) at six months (two-sided significance level alpha = 0.05; power beta = 80%). Secondary outcomes include energy-and protein balances, metabolic control, new organ failure, use of life support, nosocomial infections, ICU- and hospital length of stay, mortality and cost analyses. CONCLUSION : The optimal nutrition strategy for ICU patients remains unsettled. The EAT-ICU trial will provide important data on the effects of early goal-directed proteinenergy nutrition based on measured requirements in these patients.; Copenhagen University Hospital; Rigshospitalet; Fresenius Kabi A/S; European Society for Clinical Nutrition and Metabolism (ESPEN); SCI(E); ARTICLE; matilde.jo.allingstrup@regionh.dk; 9; 63
语种	英语
出处	SCI
出版者	DANISH MEDICAL JOURNAL
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/458903]
专题	数学科学学院
推荐引用方式 GB/T 7714	Allingstrup, Matilde Jo,Kondrup, Jens,Wiis, Jorgen,et al. Early goal-directed nutrition in ICU patients (EAT-ICU): protocol for a randomised trial. 2016-01-01.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。