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	3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data
	Li, Ruifeng ; Liu, Yifang ; Li, Tingting ; Li, Cheng
	2016
关键词	LONG-RANGE INTERACTIONS GENE-EXPRESSION REVEALS DOMAINS ARCHITECTURE PRINCIPLES TOPOLOGY LEUKEMIA
英文摘要	Chromosomal rearrangement (CR) events have been implicated in many tumor and non-tumor human diseases. CR events lead to their associated diseases by disrupting gene and protein structures. Also, they can lead to diseases through changes in chromosomal 3D structure and gene expression. In this study, we search for CR-associated diseases potentially caused by chromosomal 3D structure alteration by integrating Hi-C and ChIP-seq data. Our algorithm rediscovers experimentally verified disease-associated CRs (polydactyly diseases) that alter gene expression by disrupting chromosome 3D structure. Interestingly, we find that intellectual disability may be a candidate disease caused by 3D chromosome structure alteration. We also develop a Web server (3Disease Browser, http://3dgb.cbi.pku.edu.cn/disease/) for integrating and visualizing disease-associated CR events and chromosomal 3D structure.; Peking-Tsinghua Center for Life Sciences; SCI(E); PubMed; ARTICLE; cheng_li@pku.edu.cn; 34651; 6
语种	英语
出处	PubMed ; SCI
出版者	SCIENTIFIC REPORTS
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/457446]
专题	数学科学学院 生命科学学院
推荐引用方式 GB/T 7714	Li, Ruifeng,Liu, Yifang,Li, Tingting,et al. 3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data. 2016-01-01.

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