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	AGR2 is associated with gastric cancer progression and poor survival
	Zhang, Jun ; Jin, Yongming ; Xu, Shaonan ; Zheng, Jiayin ; Zhang, Qi ; Wang, Yuanyu ; Chen, Jinping ; Huang, Yazeng ; He, Xujun ; Zhao, Zhongsheng
	2016
关键词	anterior gradient protein 2 cathepsin D gastric cancer immunohistochemistry progression poor survival PROTEIN DISULFIDE-ISOMERASE CIRCULATING TUMOR-CELLS CATHEPSIN-D GENE-EXPRESSION BREAST-CANCER ANTERIOR GRADIENT-2 MICROVESSEL DENSITY PROSTATE-CANCER OVARIAN-CANCER METASTASIS
英文摘要	Anterior gradient protein 2 (AGR2) has been reported as a novel biomarker with a potential oncogenic role. However, its association with the prognosis and survival rate of gastric cancer (GC) has not yet been determined. Therefore, the present study aimed to examine the expression and prognostic significance of AGR2 in patients with GC. Immunohistochemistry was used to analyze AGR2 and cathepsin D (CTSD) protein expression in 436 clinicopathologically characterized GC cases and 92 noncancerous tissue samples. AGR2 and CTSD expression were both elevated in GC lesions compared with noncancerous tissues. In 204/436 (46.8%) GC patients, high expression of AGR2 was positively correlated with the expression of CTSD (r=0.577, P<0.01). Furthermore, several clinicopathological parameters were significantly associated with AGR2 expression level, including tumor size, depth of invasion and TNM stage (P<0.05). Using Kaplan-Meier survival analysis, it was determined that the mean survival time of patients with low levels of AGR2 expression was significantly longer than those with high ARG2 expression (in stages I, II and III; P<0.05). For stage IV disease, no significant difference in survival time was identified. Multivariate survival analysis demonstrated that AGR2 was an independent prognostic factor and was associated in the progression of GC. The findings of the present study indicate that AGR2 expression is significantly associated with location and size of GC, depth of invasion, TNM stage, lymphatic metastasis, vessel invasion, distant metastasis, Lauren's classification, high CTSD expression and poor prognosis. Thus, AGR2 may be a novel GC marker and may present a potential therapeutic target for GC.; Zhejiang Provincial Department of Science and Technology Research Foundation [2008C33040, 2012C33069]; Natural Scientific Research Foundation of Zhejiang Province [LY14H060006]; Natural Scientific Research Foundation of Zhejiang Medical College [2011XZB01]; SCI(E); PubMed; ARTICLE; zhaozhongsheng1950@163.com; 3; 2075-2083; 11
语种	英语
出处	SCI ; PubMed
出版者	ONCOLOGY LETTERS
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/434428]
专题	数学科学学院
推荐引用方式 GB/T 7714	Zhang, Jun,Jin, Yongming,Xu, Shaonan,et al. AGR2 is associated with gastric cancer progression and poor survival. 2016-01-01.

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