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	A General Analysis of Single IP(3) Receptors Modulated by Cytosolic Ca(2+) and IP(3)
	Jia, Chen ; Li, Yihan ; Qian, Minping
	2009
关键词	INOSITOL TRISPHOSPHATE RECEPTOR XENOPUS-OOCYTES SPATIAL-DISTRIBUTION CALCIUM ACTIVATION KINETICS RELEASE MODEL PUFFS
英文摘要	In this report, we remove the constraint of detailed balance and give a general discussion of the modulation of cytosolic Ca(2+) and IP(3) on the IP(3)R channel. By introducing the circulation decomposition theorem in stochastic process, the gating mechanism of single IP(3)R is neatly analyzed. Some remarkable differences are found to distinguish between equilibrium and non-equilibrium dynamics. Evidence is given to show that detailed balance is violated to some extent in the IP(3)R channel. Comparison of surface fittings between equilibrium and non-equilibrium models reveals that the latter model excels evidently. It is emphasized that these interesting phenomena in the non-equilibrium dynamics, present a more comprehensive view of the channel behavior.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281131900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Mathematical & Computational Biology; CPCI-S(ISTP); 0
语种	英语
出处	SCI
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/315408]
专题	数学科学学院
推荐引用方式 GB/T 7714	Jia, Chen,Li, Yihan,Qian, Minping. A General Analysis of Single IP(3) Receptors Modulated by Cytosolic Ca(2+) and IP(3). 2009-01-01.

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