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	Using graphical adaptive lasso approach to construct transcription factor and microRNA's combinatorial regulatory network in breast cancer
	Su, Naifang ; Dai, Ding ; Deng, Chao ; Qian, Minping ; Deng, Minghua
	2014
关键词	cancer RNA molecular biophysics molecular configurations genetics biological organs Gaussian processes graphs feedforward biology computing graphical adaptive lasso approach transcription factor microRNA combinatorial regulatory network breast cancer cancer-related gene regulation cancer biology gene expression combinatorial regulatory network network structure molecular pathway GALASSO Gaussian graphical model adaptive lasso penalties sequence information gene e TARGETS SELECTION DEREGULATION SEQUENCES DATABASE GENES CELLS
英文摘要	Discovering the regulation of cancer-related gene is of great importance in cancer biology. Transcription factors and microRNAs are two kinds of crucial regulators in gene expression, and they compose a combinatorial regulatory network with their target genes. Revealing the structure of this network could improve the authors' understanding of gene regulation, and further explore the molecular pathway in cancer. In this article, the authors propose a novel approach graphical adaptive lasso (GALASSO) to construct the regulatory network in breast cancer. GALASSO use a Gaussian graphical model with adaptive lasso penalties to integrate the sequence information as well as gene expression profiles. The simulation study and the experimental profiles verify the accuracy of the authors' approach. The authors further reveal the structure of the regulatory network, and explore the role of feedforward loops in gene regulation. In addition, the authors discuss the combinatorial regulatory effect between transcription factors and microRNAs, and select miR-155 for detailed analysis of microRNA's role in cancer. The proposed GALASSO approach is an efficient method to construct the combinatorial regulatory network. It also provides a new way to integrate different data sources and could find more applications in meta-analysis problem.; Cell Biology; Mathematical & Computational Biology; SCI(E); EI; PubMed; 0; ARTICLE; dengmh@pku.edu.cn; 3,SI; 87-95; 8
语种	英语
出处	PubMed ; SCI
出版者	iet systems biology
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/314164]
专题	数学科学学院
推荐引用方式 GB/T 7714	Su, Naifang,Dai, Ding,Deng, Chao,et al. Using graphical adaptive lasso approach to construct transcription factor and microRNA's combinatorial regulatory network in breast cancer. 2014-01-01.

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