Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy

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	Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy
	Yang, Yang; Lin, Yuanzhe; Di, Donghua; Zhang, Xing; Wang, Da; Zhao, Qinfu; Wang, Siling; Zhao, QF; Wang, SL (reprint author), Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
刊名	ACADEMIC PRESS INC ELSEVIER SCIENCE
	2017-12-15
卷号	508 页码:323-331
关键词	Mesoporous Silica Nanoparticles Gold Nanoparticles Photothermal Therapy Near-infrared Doxorubicin
ISSN号	0021-9797
英文摘要	In this paper, a redox-triggered drug delivery system of DOX/MSN-Au was prepared for chemo-photothermal synergistic therapy. The ultra-small gold nanoparticles (NPs) were appended to the openings of mesoporous silica nanoparticles (MSN) by Au-S bonds as the gatekeepers. Meanwhile, the gold NPs could be heated to high temperature by the near infrared (NIR) light irradiation, which is conducive to photothermal therapy. X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectrometer (FT-IR) spectra confirmed the formation of MSN-SH and MSN-Au. An in vitro NIR-induced photothermal study indicated that MSN-Au possessed concentration-dependent and power dependent photothermal conversion capacity. Doxorubicin (DOX) was selected as the model drug loaded in the MSN. In vitro drug release showed that DOX released faster in the presence of glutathione (GSH) or NIR laser irradiation than without GSH or NIR irradiation, which suggested that the system had potentials for redox-responsive and NIR-triggered drug release. Confocal Laser Scanning Microscope (CLSM) was performed to evaluate the cellular uptake performance of DOX/MSN-Au. The cytotoxicity assay indicated that DOX/MSN-Au had a synergistic therapeutic effect by the combination of chemotherapy and photothermal therapy. This work suggested that MSN-Au could be explored as a redox-triggered drug delivery system for the chemo-photothermal synergistic therapy. (C) 2017 Elsevier Inc. All rights reserved.; In this paper, a redox-triggered drug delivery system of DOX/MSN-Au was prepared for chemo-photothermal synergistic therapy. The ultra-small gold nanoparticles (NPs) were appended to the openings of mesoporous silica nanoparticles (MSN) by Au-S bonds as the gatekeepers. Meanwhile, the gold NPs could be heated to high temperature by the near infrared (NIR) light irradiation, which is conducive to photothermal therapy. X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectrometer (FT-IR) spectra confirmed the formation of MSN-SH and MSN-Au. An in vitro NIR-induced photothermal study indicated that MSN-Au possessed concentration-dependent and power dependent photothermal conversion capacity. Doxorubicin (DOX) was selected as the model drug loaded in the MSN. In vitro drug release showed that DOX released faster in the presence of glutathione (GSH) or NIR laser irradiation than without GSH or NIR irradiation, which suggested that the system had potentials for redox-responsive and NIR-triggered drug release. Confocal Laser Scanning Microscope (CLSM) was performed to evaluate the cellular uptake performance of DOX/MSN-Au. The cytotoxicity assay indicated that DOX/MSN-Au had a synergistic therapeutic effect by the combination of chemotherapy and photothermal therapy. This work suggested that MSN-Au could be explored as a redox-triggered drug delivery system for the chemo-photothermal synergistic therapy. (C) 2017 Elsevier Inc. All rights reserved.
学科主题	Chemistry, Physical
语种	英语
资助机构	National Natural Science Foundation of China [81603058, 81473165]; Liaoning Provincial Key Laboratory of Drug Preparation Design & Evaluation of Liaoning Provincial Education Department [LZ2015068]; Doctoral Research Funding of Liaoning Province [201601146]; Career Development Program for Young Teachers in Shenyang Pharmaceutical University [ZQN2016025]
公开日期	2018-01-10
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/78931]
专题	金属研究所_中国科学院金属研究所
通讯作者	Zhao, QF; Wang, SL (reprint author), Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
推荐引用方式 GB/T 7714	Yang, Yang,Lin, Yuanzhe,Di, Donghua,et al. Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy[J]. ACADEMIC PRESS INC ELSEVIER SCIENCE,2017,508:323-331.
APA	Yang, Yang.,Lin, Yuanzhe.,Di, Donghua.,Zhang, Xing.,Wang, Da.,...&Wang, SL .(2017).Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy.ACADEMIC PRESS INC ELSEVIER SCIENCE,508,323-331.
MLA	Yang, Yang,et al."Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy".ACADEMIC PRESS INC ELSEVIER SCIENCE 508(2017):323-331.