Study on antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber

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	Study on antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber
	Wu, Wei; Chen, Jia; Sun, Da; Kong, Xiangjun; Xu, Dake; Wang, Yi; Luo, Li; Zhang, Kun; Xiao, Keshen; Wang, Guixue
刊名	ELSEVIER SCIENCE BV
	2017-12-15
卷号	209 页码:562-565
关键词	Biomaterials Nanoparticles Phosphorous-magnesium Fiber Antibacterial Performance Zebrafish
ISSN号	0167-577X
英文摘要	The present study was intended to investigate the antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber (PMF). The PMF was found to exhibit excellent antibacterial performance against methicillin-resistant Staphylococcus aureus and Candida albicans, exceeding 95% when the PMF concentration was higher than 500 mu g mL (-1). MTS analysis was performed to assess the in vitro cytotoxicity of PMF, which showed PMF with a concentration range of 100-1000 mg L (-1) had no significant toxic effects on L929 fibroblast cells. In addition, the in vivo toxicity assay of PMF was studied in zebrafish (Danio rerio) embryos, and the results confirmed little toxicity at effective antibacterial concentration. Hence, PMF was proved to be a potential coating or filling material with promising antibacterial performance for in implantable medical devices. (c) 2017 Elsevier B.V. All rights reserved.; The present study was intended to investigate the antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber (PMF). The PMF was found to exhibit excellent antibacterial performance against methicillin-resistant Staphylococcus aureus and Candida albicans, exceeding 95% when the PMF concentration was higher than 500 mu g mL (-1). MTS analysis was performed to assess the in vitro cytotoxicity of PMF, which showed PMF with a concentration range of 100-1000 mg L (-1) had no significant toxic effects on L929 fibroblast cells. In addition, the in vivo toxicity assay of PMF was studied in zebrafish (Danio rerio) embryos, and the results confirmed little toxicity at effective antibacterial concentration. Hence, PMF was proved to be a potential coating or filling material with promising antibacterial performance for in implantable medical devices. (c) 2017 Elsevier B.V. All rights reserved.
学科主题	Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
资助机构	National Natural Science Foundation of China [11332003, 31370949, 81400329, 51603023]; National Key Research and Development Program [2016YFC1102305]; Fundamental Research Funds for the Central Universities [106112016CDJXY230002, 106112016CDJXY230001]; China Postdoctoral Science Foundation [2016M602656, 2017T100682]; Chongqing Postdoctoral Scientific Research Foundation [Xm2016011]; Chongqing Research Program of Basic research and Frontier Technology [cstc2017jcyjAX0186]; Chongqing Engineering Laboratory in Vascular Implants; Public Experiment Center of State Bioindustrial Base (Chongqing)
公开日期	2018-01-10
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/78932]
专题	金属研究所_中国科学院金属研究所
通讯作者	Wang, GX (reprint author), Chongqing Univ, Bioengn Coll, State & Local Joint Engn Lab Vasc Implants, Key Lab Biorheol Sci & Technol,Minist Educ, Chongqing 400044, Peoples R China.; Sun, D (reprint author), Wenzhou Univ, Inst Life Sci, Wenzhou 325000, Peoples R China.; Xiao, KS (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China.
推荐引用方式 GB/T 7714	Wu, Wei,Chen, Jia,Sun, Da,et al. Study on antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber[J]. ELSEVIER SCIENCE BV,2017,209:562-565.
APA	Wu, Wei.,Chen, Jia.,Sun, Da.,Kong, Xiangjun.,Xu, Dake.,...&Xiao, KS .(2017).Study on antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber.ELSEVIER SCIENCE BV,209,562-565.
MLA	Wu, Wei,et al."Study on antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber".ELSEVIER SCIENCE BV 209(2017):562-565.