Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials

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	Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials
	Li, SJ; Li, XK; Hou, WT; Nune, KC; Misra, RDK; Correa-Rodriguez, VL; Guo, Z; Hao, YL; Yang, R; Murr, LE
刊名	SCIENCE CHINA-MATERIALS
	2018-04-01
卷号	61 期号:4 页码:525-536
关键词	Next-generation Mesh Arrays In-vivo Bone Scaffolds Angiogenesis Osteogenesis Technologies Constructs Interplay
ISSN号	2095-8226
英文摘要	In this study we describe the fabrication of a variety of open-cellular titanium alloy (Ti-6Al-4V) implants, both reticular mesh and foam structures, using electron beam melting (EBM). These structures allow for the elimination of stress shielding by adjusting the porosity (or density) to produce an elastic modulus (or stiffness) to match that of both soft (trabecular) and hard (cortical) bone, as well as allowing for bone cell ingrowth, increased cell density, and all-matrix interactions; the latter involving the interplay between bone morphogenetic protein (BMP-2) and osteoblast functions. The early formation and characterization of elementary vascular structures in an aqueous hydrogel matrix are illustrated. Preliminary results for both animal (sheep) and human trials for a number of EBM-fabricated, and often patient-specific Ti-alloy implants are also presented and summarized. The results, while preliminary, support the concept and development of successful, porous, engineered "living" implants.; In this study we describe the fabrication of a variety of open-cellular titanium alloy (Ti-6Al-4V) implants, both reticular mesh and foam structures, using electron beam melting (EBM). These structures allow for the elimination of stress shielding by adjusting the porosity (or density) to produce an elastic modulus (or stiffness) to match that of both soft (trabecular) and hard (cortical) bone, as well as allowing for bone cell ingrowth, increased cell density, and all-matrix interactions; the latter involving the interplay between bone morphogenetic protein (BMP-2) and osteoblast functions. The early formation and characterization of elementary vascular structures in an aqueous hydrogel matrix are illustrated. Preliminary results for both animal (sheep) and human trials for a number of EBM-fabricated, and often patient-specific Ti-alloy implants are also presented and summarized. The results, while preliminary, support the concept and development of successful, porous, engineered "living" implants.
学科主题	Materials Science, Multidisciplinary
语种	英语
资助机构	Ministry of Science and Technology [2017YFC1104900, 2016YFC1102601]; National Natural Science Foundation of China [51271182, 51631007]; Chinese Academy of Sciences [QYZDJ-SSW-JSC031]; Department of Metallurgical, Materials and Biomedical Engineering; Office of Research and Sponsored Projects at the University of Texas at El Paso
公开日期	2018-06-05
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/79381]
专题	金属研究所_中国科学院金属研究所
通讯作者	Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.
推荐引用方式 GB/T 7714	Li, SJ,Li, XK,Hou, WT,et al. Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials[J]. SCIENCE CHINA-MATERIALS,2018,61(4):525-536.
APA	Li, SJ.,Li, XK.,Hou, WT.,Nune, KC.,Misra, RDK.,...&Guo, Z .(2018).Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials.SCIENCE CHINA-MATERIALS,61(4),525-536.
MLA	Li, SJ,et al."Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials".SCIENCE CHINA-MATERIALS 61.4(2018):525-536.