Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy

doi:10.1016/j.pedneo.2017.10.003

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	Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy
	Duan SF(段绍峰); Dan BC(单保慈); Nie, Binbin; Duan, Shaofeng; Ma, Qiaozhi; Dai, Guanghui; Wu, Chunnan; Dong, Yuru; Shan, Baoci; Ma, Lin
刊名	PEDIATRICS & NEONATOLOGY
	2018
卷号	59 期号:4 页码:345-351
关键词	cerebral palsy functional connectivity magnetic resonance imaging regional homogeneity resting-state functional magnetic resonance imaging
ISSN号	1875-9572
DOI	10.1016/j.pedneo.2017.10.003
文献子类	Article
英文摘要	Background: Very few studies have been made to investigate functional activity changes in occult spastic diplegic cerebral palsy (SDCP). The purpose of this study was to analyze whole-brain resting state regional brain activity and functional connectivity (FC) changes in patients with SDCP. Methods: We examined 12 occult SDCP and 14 healthy control subjects using resting-state functional magnetic resonance imaging. The data were analyzed using Resting-State fMRI Data Analysis Toolkit (REST) software. The regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and whole brain FC of the motor cortex and thalamus were analyzed and compared between the occult SDCP and control groups. Results: Compared with the control group, the occult SDCP group showed decreased ReHo regions, including the bilateral frontal, parietal, and temporal lobes, the cerebellum, right cingulate gyrus, and right lenticular nucleus, whereas an increased ReHo value was observed in the left precuneus, calcarine, fusiform gyrus, and right precuneus. Compared with the control group, no significant differences in ALFF were noted in the occult SDCP group. With the motor cortex as the region of interest, the occult SDCP group showed decreased connectivity regions in the bilateral fusiform and lingual gyrus, but increased connectivity regions in the contralateral precentral and postcentral gyrus, supplementary motor area, and the ipsilateral postcentral gyrus. With the thalamus being regarded as the region of interest, the occult SDCP group showed decreased connectivity regions in the bilateral basal ganglia, cingulate, and prefrontal cortex, but increased connectivity regions in the bilateral precentral gyrus, the contralateral cerebellum, and inferior temporal gyrus. Conclusions: Resting-state regional brain activities and FC changes in the patients with occult SDCP exhibited a special distribution pattern, which is consistent with the pathology of the disease. Copyright (C) 2017, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.
电子版国际标准刊号	2212-1692
WOS关键词	BRAIN ACTIVITY ; PERIVENTRICULAR LEUKOMALACIA ; FUNCTIONAL CONNECTIVITY ; CHILDREN ; CLASSIFICATION ; DEFINITION ; DEFICITS ; INJURY ; DAMAGE
WOS研究方向	Chemistry ; Materials Science
语种	英语
WOS记录号	WOS:000454041700004
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286700]
专题	高能物理研究所_核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Duan SF,Dan BC,Nie, Binbin,et al. Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy[J]. PEDIATRICS & NEONATOLOGY,2018,59(4):345-351.
APA	段绍峰.,单保慈.,Nie, Binbin.,Duan, Shaofeng.,Ma, Qiaozhi.,...&Mu, Xuetao.(2018).Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy.PEDIATRICS & NEONATOLOGY,59(4),345-351.
MLA	段绍峰,et al."Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy".PEDIATRICS & NEONATOLOGY 59.4(2018):345-351.