Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy

doi:10.1002/ppsc.201800127

	Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy
	Yu, M; Li, ZL; Hu, SS; Liu J(刘晶); Chen CY(陈春英); Liu, J; Hu, Y; Chen, L; Jiang, TT; Sun, L
刊名	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
	2018
卷号	35 期号:8 页码:1800127
关键词	cobalt phosphide nanoparticles magnetic resonance imaging photoacoustic imaging photothermal therapy theranostic nanoagent
ISSN号	0934-0866
DOI	10.1002/ppsc.201800127
文献子类	Article
英文摘要	Biocompatible single-component theranostic nanoagents instinctly affording multiple imaging modalities with satisfying therapeutic functions are highly desirable for anticancer treatments. Although cobalt-based phosphides are well-recognized as competent electrocatalysts, their potentials for biomedical applications remain unexplored. In this work, cobalt phosphide nanoparticles (CoP NPs) are developed to be a powerful theranostic agent for multimodal imaging and anticancer photothermal therapy. The uniform CoP NPs in a size of approximate to 21 nm are synthesized via a facile thermal decomposition method, followed by surface modification. The resultant CoP NPs exhibit excellent compatibility and stability in water as well as various physiological solutions. Supported by the good biocompatibility, strong near-infrared absorption, and high photothermal conversion property, significant photothermal effect of the NPs is demonstrated, realizing efficient hyperthermia ablation on cancer cells. Importantly, the CoP NPs have shown considerable capabilities on high-contrast in vitro and in vivo triple-modal imaging, including infrared thermal (IRT), photoacoustic (PA), and T-2-weighted magnetic resonance (MR) imaging. This work has unraveled the promising potentials of CoP-based nanoagent for precise diagnosis and efficient therapy.
电子版国际标准刊号	1521-4117
WOS关键词	PRUSSIAN BLUE NANOPARTICLES ; LAYER MOS2 NANOSHEETS ; NEAR-INFRARED LIGHT ; DRUG-DELIVERY ; CANCER-THERAPY ; NANOCRYSTALS ; ABLATION ; GRAPHENE ; NANODOTS ; PLATFORM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000441893400010
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286230]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心高能物理研究所_粒子天体物理中心高能物理研究所_理论物理室
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yu, M,Li, ZL,Hu, SS,et al. Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2018,35(8):1800127.
APA	Yu, M.,Li, ZL.,Hu, SS.,刘晶.,陈春英.,...&Chen, CY.(2018).Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,35(8),1800127.
MLA	Yu, M,et al."Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 35.8(2018):1800127.