Twirling reinforcing-reducing manipulation  central mechanism underlying antihypertensive effect on spontaneous hypertension in rats

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	Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats
	Liu, QG; Sun, DM; Nie, BB; Nie BB(聂彬彬); Guo, QL
刊名	JOURNAL OF TRADITIONAL CHINESE MEDICINE
	2018
卷号	38 期号:3 页码:391-398
关键词	Twirling reinforcing reducing method Hypertension Blood pressure Positron-Emission tomography Central mechanism
ISSN号	0255-2922
文献子类	Article
英文摘要	OBJECTIVE: To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation (TRRM) might be the central mechanism underlying the action. METHODS: In the study, 18F-2-fluoro-deoxy-D-glucose positron emission tomography (18F-FDG-PET) was employed. Fifity-six spontaneous hypertensive rats (SHRs) were randomly divided into a model group, a single-needle acupuncture (SNA) group, a twirling reinforcing group (SNA + TRF) and a twirling reducing (SNA + TRD) group. Fourteen Wistar rats were assigned to the control group. The acupuncture intervention at Taichong (LR 3) acupoint was administered once daily in the SNA, SNA + TRF and SNA + TRD groups for 14 days, with 1 d interval between the two weeks. The blood pressure (BP) of all rats was measured repeatedly and 18F-FDG-PET scans were conducted on the 14th day. PET images were processed with Statistical Parametric Mapping 8.0. RESULTS: After the intervention, systolic BP showed a significant decrease in the SNA, SNA+TRF and SNA + TRD versus the model groups (all P < 0.01) and in the SNA + TRF and SNA + TRD versus the SNA groups (both P < 0.01), with the SNA + TRD group exhibited the best antihypertensive effect (P < 0.01). The key brain regions activated by TRRM were mainly concentrated in the cerebellum, hippocampus, hypothalamus, medulla oblongata, insular cortex, midbrain, thalamus and visual cortex. CONCLUTION: TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission. (C) 2018 JTCM. All rights reserved.
电子版国际标准刊号	1577-7014
WOS关键词	HYPOTHALAMIC PARAVENTRICULAR NUCLEUS ; SYMPATHETIC VASOMOTOR TONE ; RENIN-ANGIOTENSIN SYSTEM ; BLOOD-PRESSURE ; ROSTROVENTROLATERAL MEDULLA ; ACUPUNCTURE ; BRAIN ; NEURONS ; INPUTS ; TRIAL
WOS研究方向	Integrative & Complementary Medicine
语种	英语
CSCD记录号	CSCD:6260600
WOS记录号	WOS:000436368600008
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286059]
专题	高能物理研究所_核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liu, QG,Sun, DM,Nie, BB,et al. Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2018,38(3):391-398.
APA	Liu, QG,Sun, DM,Nie, BB,聂彬彬,&Guo, QL.(2018).Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats.JOURNAL OF TRADITIONAL CHINESE MEDICINE,38(3),391-398.
MLA	Liu, QG,et al."Twirling reinforcing-reducing manipulation central mechanism underlying antihypertensive effect on spontaneous hypertension in rats".JOURNAL OF TRADITIONAL CHINESE MEDICINE 38.3(2018):391-398.