Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life

doi:10.2147/IJN.S160828

	Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life
	Gu ZJ(谷战军); Gao, JW; Fu, JJ; Fan, XT; Zhu, JC; Gu, ZJ; Xu, HW; Ma, YY; Gong, LJ; Gong LJ(龚林吉)
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2018
卷号	13 页码:3593-3608
关键词	silica nanoparticles nanotoxicity hippocampal neurogenesis neuroinfla mation social behavior
ISSN号	1178-2013
DOI	10.2147/IJN.S160828
文献子类	Article
英文摘要	Introduction: Silica nanoparticles (SiO2-NPs) are currently among the most widely used nanomaterials, but their potentially adverse effects on brain development remain unknown. The developing brain is extremely sensitive to NP neurotoxicity during the early postnatal period. Materials and methods: Herein, we investigated the effects of SiO2-N Ps (doses of 10, 20, or 50 mg with a particle size of similar to 91 nm, equivalent to aerosol mass concentrations 55.56, 111.11, and 277.78 mg/m(3), respectively) exposure from postnatal day (P) 1 to P7 on hippocampal precursor proliferation at P8 and long-term neurobehavior in adults. Results: SiO2-NP exposure resulted in inflammatory cell infiltration in lung tissue, microglia over-activation in the hippocampal dentate gyrus (DG), and decreased hippocampal precursor proliferation in the DG-subgranular zone at P8. Moreover, after exposure to 20 mg of SiO2-NPs, mice exhibited social interaction deficits and slight anxiety-like behaviors in adulthood, but this exposure did not induce locomotor activity impairment, depression-like behavior, or short-term memory impairment. Discussion: These findings suggest that early-age SiO2-NP exposure induced inflammation and inhibited precursor proliferation in the DG in a dose-dependent manner, which might be related to the social dysfunction observed in adulthood.
WOS关键词	BRAIN-BARRIER DYSFUNCTION ; NEURAL STEM-CELLS ; IN-VITRO ; INTRATRACHEAL INSTILLATION ; INFLAMMATORY RESPONSES ; DIOXIDE NANOPARTICLES ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; AIR-POLLUTION ; MOUSE MODEL
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000436025200001
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286042]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gu ZJ,Gao, JW,Fu, JJ,et al. Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:3593-3608.
APA	谷战军.,Gao, JW.,Fu, JJ.,Fan, XT.,Zhu, JC.,...&龚林吉.(2018).Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,3593-3608.
MLA	谷战军,et al."Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):3593-3608.