Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa

doi:10.1016/j.nano.2017.12.013

	Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa
	Li, JX; Xing GM(邢更妹); Zhao LN(赵丽娜); Gu WH(古伟宏); Chen K(陈奎); Chang YN(常亚男); Liu JK(刘金珂); Zu M(祖勉); Li J(李娟); Xia SB(夏士博)
刊名	NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE
	2018
卷号	14 期号:3 页码:929-939
关键词	Fullerenols Anticoagulation Thrombin FXa Ca2+ Inhibition of thrombosis
ISSN号	1549-9634
DOI	10.1016/j.nano.2017.12.013
文献子类	Article
英文摘要	Thrombus is one of main causes of death in the world and also a vital trouble of biomaterials application in vivo. Recently, effect of fullerenol nanomaterials on anticoagulation was found in our research through extension of bleeding times in treated Sprague-Dawley rats via intravenous injection. Inhibiting of fullerenols on thrombosis was ascertained further by thromboembolism model. Effects of fullerenols on intrinsic and extrinsic pathway were distinct in prolonging activated partial thromboplastin time and prothrombin time, which supported that fullerenols induced defects in both pathways. Inhibited activities of activated coagulation factor X (FXa) and thrombin were verified by experiments in vitro and AutoDock Vina. The results suggest that fullerenols depending on small size and certainly surface property occupied the active domain of FXa and thrombin to block their activity; further, thrombosis was inhibited. This putative mechanism offers an insight into how fullerenol NPs were utilized further in biomedical applications. (c) 2018 Elsevier Inc. All rights reserved.
电子版国际标准刊号	1549-9642
WOS关键词	PLATELET-AGGREGATION ; ANTITHROMBOTIC ACTIVITIES ; PROCOAGULANT ACTIVITY ; STEM-CELLS ; IN-VITRO ; FIBRINOGEN ; ANTICOAGULANT ; BINDING ; PERMEABILITY ; SUPPRESSION
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
语种	英语
WOS记录号	WOS:000429528900027
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285806]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Li, JX,Xing GM,Zhao LN,et al. Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa[J]. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE,2018,14(3):929-939.
APA	Li, JX.,邢更妹.,赵丽娜.,古伟宏.,陈奎.,...&Xing, GY.(2018).Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa.NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE,14(3),929-939.
MLA	Li, JX,et al."Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa".NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE 14.3(2018):929-939.