Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-beta signaling | |
Liu, Jing-Xia1,2; Xu, Qin-Han1; Li, Sen3; Yu, XueDong1; Liu, Wenye1; Ouyang, Gang2; Zhang, Ting1; Chen, Ling-Ling3 | |
刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS |
2017-10-01 | |
卷号 | 1860期号:10页码:1103-1116 |
关键词 | Eaf1/2 TGF-beta P53 Mesoderm Endoderm |
ISSN号 | 1874-9399 |
DOI | 10.1016/j.bbagrm.2017.09.001 |
英文摘要 | Eaf family genes act in multiple cellular responses such as tumor suppression and embryonic development. In our previous work, Eaf1/2 was found to modulate convergence and extension (C & E) movements and pattern the embryonic anterior-posterior axis during zebrafish embryogenesis. Here, we found that loss-of-function of eaf1/2 caused expanded mesoderm and endoderm in zebrafish embryos and led to the recovery of endoderm specification in TGF-beta factor-mzoep(tz257) mutants, while gain-of-function of eaf1/2 induced reduced mesoderm and endoderm. Analyses of gene expression profiles in Eaf deleted or over-expressed mammalian cells indicated that the roles of Eaf1 and Eaf2 in inhibiting TGF-beta signals were conserved from fish to mammals. By taking advantages of TGF-beta reporters, eaf1/2-fused engrailed proteins, and P53(M214K) mutant, we revealed that Eaf1 and Eaf2 might suppress TGF-beta transduction by synergistically inhibiting none-P53 and P53-required TGF-beta signaling. Furthermore, Eaf1/2 might co-localize and interact with TGF-beta transcriptional factors in the transcriptional complex as repressors to target and suppress TGF-beta signaling activity. Our study unveiled a previously unrecognized link of Eaf1/2 genes with TGF-beta and P53 in vertebrates and demonstrated a conservation of TGF-beta suppression activity for Eaf1/2 family genes from fish to mammals, which might shed some light on the molecular mechanistic basis of Eaf1 and Eaf2 in tumor suppression. |
资助项目 | Huazhong Agricultural University Scientific & Technological Self-innovation Foundation[42000481-7-2014RC007] ; Fundamental Research Funds for the Central University[2662015PY002] ; Chinese Academy of Sciences[KSCX2-EW-Q-12] |
WOS关键词 | ZEBRAFISH ; P53 ; EXPRESSION ; EAF2 ; SUPERFAMILY ; PROTEIN ; GROWTH ; GENES ; DIFFERENTIATION ; GASTRULATION |
WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000413615400009 |
资助机构 | Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; 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Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Fundamental Research Funds for the Central University ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; Huazhong Agricultural University Scientific & Technological Self-innovation Foundation ; 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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/32630] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Liu, Jing-Xia |
作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Key Lab Freshwater Anim Breeding, Minist Agr, Wuhan 430070, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan 430072, Hubei, Peoples R China 3.Huazhong Agr Univ, Coll Informat, Agr Bioinformat Key Lab Hubei Prov, Wuhan 430070, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Jing-Xia,Xu, Qin-Han,Li, Sen,et al. Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-beta signaling[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2017,1860(10):1103-1116. |
APA | Liu, Jing-Xia.,Xu, Qin-Han.,Li, Sen.,Yu, XueDong.,Liu, Wenye.,...&Chen, Ling-Ling.(2017).Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-beta signaling.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1860(10),1103-1116. |
MLA | Liu, Jing-Xia,et al."Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-beta signaling".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1860.10(2017):1103-1116. |
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