Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain | |
Khan, Suliman1,2,3,4; Liu, Yang4,5; Siddique, Rabeea4,5; Nabi, Ghulam1,3; Xue, Mengzhou4,5; Hou, Hongwei1,3 | |
刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
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2019 | |
卷号 | 15期号:9页码:1816-1834 |
关键词 | Circadian Rhythm Clock Genes Glioma Oncogenes Tumor Suppressor Genes |
ISSN号 | 1449-2288 |
DOI | 10.7150/ijbs.35520 |
英文摘要 | Disruption of the circadian rhythm is a risk factor for cancer, while glioma is a leading contributor to mortality worldwide. Substantial efforts are being undertaken to decrypt underlying molecular pathways. Our understanding of the mechanisms through which disrupted circadian rhythm induces glioma development and progression is incomplete. We, therefore, examined changes in the expression of glioma-related genes in the mouse brain after chronic jetlag (CJL) exposure. A total of 22 candidate tumor suppressor (n= 14) and oncogenes (n= 8) were identified and analyzed for their interaction with clock genes. Both the control and CJL groups were investigated for the expression of candidate genes in the nucleus accumbens, hippocampus, prefrontal cortex, hypothalamus, and striatum of wild type, Bmal1(-/-) and Cry1/2 double knockout male mice. We found significant variations in the expression of candidate tumor suppressor and oncogenes in the brain tissues after CJL treatment in the wild type, Bmal1(-/-) and Cry1/2 double knockout mice. In response to CJL treatment, some of the genes were regulated in the wild type, Bmal1(-/-) and Cry1/2 similarly. However, the expression of some of the genes indicated their association with the functional clock. Overall, our result suggests a link between CJL and gliomas risk at least partially dependent on the circadian clock. However, further studies are needed to investigate the molecular mechanism associated with CJL and gliomas. |
资助项目 | National Science Foundation of China[31870917] ; National Science Foundation of China[81471174] ; National Science Foundation of China[81520108011] ; National Science Foundation of China[81870942] ; National Key Research and Development Program of China[2018YFC1312200] ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China |
WOS关键词 | SHIFT WORK ; RISK ; DATABASE ; DISRUPTION ; POLYMORPHISMS ; ASSOCIATION ; METHYLATION ; MECHANISMS ; ACCUMBENS ; GENETICS |
WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
语种 | 英语 |
出版者 | IVYSPRING INT PUBL |
WOS记录号 | WOS:000481578100004 |
资助机构 | National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China ; 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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/33210] ![]() |
专题 | 水生生物研究所_中科院水生所知识产出(2009年前) |
通讯作者 | Xue, Mengzhou; Hou, Hongwei |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China 2.Minist Educ, Key Lab Mol Biophys, Wuhan 430074, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Henan, Peoples R China 5.Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Henan, Peoples R China |
推荐引用方式 GB/T 7714 | Khan, Suliman,Liu, Yang,Siddique, Rabeea,et al. Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(9):1816-1834. |
APA | Khan, Suliman,Liu, Yang,Siddique, Rabeea,Nabi, Ghulam,Xue, Mengzhou,&Hou, Hongwei.(2019).Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(9),1816-1834. |
MLA | Khan, Suliman,et al."Impact of chronically alternating light-dark cycles on circadian clock mediated expression of cancer (glioma)-related genes in the brain".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.9(2019):1816-1834. |
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