Potential effect of germanium exposure on the risk of influenza-like illness in housewives in Shanxi Province, China

doi:10.1016/j.scitotenv.2019.05.103

	Potential effect of germanium exposure on the risk of influenza-like illness in housewives in Shanxi Province, China
	Pang, Yiming 1,2; Guo, Yunhe 3; Li, Kexin 4; Ren, Mengyuan 1,2; Jia, Xiaoqian 1,2; Li, Zewu 1,2; Wang, Bin 1,2; Yan, Lailai 5; Li, Zhiwen 1,2
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2019-09-10
卷号	682 页码:208-212
关键词	Influenza-like illness Hair Germanium SNPs Interaction effect
ISSN号	0048-9697
DOI	10.1016/j.scitotenv.2019.05.103
通讯作者	Wang, Bin(binwangpku@foxmail.com) ; Yan, Lailai(yll@bjmu.edu.cn)
英文摘要	Few studies have examined the relationship between exposure to germanium (Ge) and the risk of influenza-like illness (ILI). Therefore, we investigated the association of Ge exposure and its interaction with single nucleotide polymorphisms (SNPs) related to Phase II metabolism on ILI risk among housewives in Shanxi Province, northern China. This cross-sectional study enrolled 373 housewives. Information on the housewives' characteristics and the frequency of ILI was collected by questionnaire. We analyzed the Ge concentrations in hair samples taken from near the scalp at the back of the head. Blood samples were used to identify SNPs related to Phase II metabolism. The results suggested that the hair Ge concentration was associated with ILI risk with an adjusted odds ratio and 95% confidence interval of 2.59 (1.61-4.19). A significant dose-response relationship was observed without or with adjusting for confounders. We did not observe any interaction effect between the hair Ge concentration and the SNPs on ILI risk. We found that high dietary consumption of meat and fried foods was positively correlated with the hair Ge concentration. Therefore, chronic Ge exposure may be a risk factor for an increased frequency of ILI in housewives. (C) 2019 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[41771527] ; National Natural Science Foundation of China[81373014] ; National Natural Science Foundation of China[41830641] ; Interdisciplinary Medicine Seed Fund of Peking University[BMU2017MX006]
WOS关键词	MICROSOMAL EPOXIDE HYDROLASE ; INDOOR AIR-POLLUTION ; POLYMORPHISM ; ASSOCIATION ; INFECTION ; GENE ; SUSCEPTIBILITY ; NEPHROTOXICITY ; APOPTOSIS ; ELEMENTS
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000471888900018
资助机构	National Natural Science Foundation of China ; Interdisciplinary Medicine Seed Fund of Peking University
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/58751]
专题	中国科学院地理科学与资源研究所
通讯作者	Wang, Bin; Yan, Lailai
作者单位	1.Peking Univ, Inst Reprod & Child Hlth, Key Lab Reprod Hlth, Natl Hlth Commiss Peoples Republ China, Beijing 100191, Peoples R China 2.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China 3.Beijing Normal Univ, Sch Environm, Beijing 100875, Peoples R China 4.Chinese Acad Sci, Key Lab Land Surface Pattern & Simulat, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China 5.Peking Univ, Dept Laboratorial Sci & Technol, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Pang, Yiming,Guo, Yunhe,Li, Kexin,et al. Potential effect of germanium exposure on the risk of influenza-like illness in housewives in Shanxi Province, China[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,682:208-212.
APA	Pang, Yiming.,Guo, Yunhe.,Li, Kexin.,Ren, Mengyuan.,Jia, Xiaoqian.,...&Li, Zhiwen.(2019).Potential effect of germanium exposure on the risk of influenza-like illness in housewives in Shanxi Province, China.SCIENCE OF THE TOTAL ENVIRONMENT,682,208-212.
MLA	Pang, Yiming,et al."Potential effect of germanium exposure on the risk of influenza-like illness in housewives in Shanxi Province, China".SCIENCE OF THE TOTAL ENVIRONMENT 682(2019):208-212.