Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg

	Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg
	Li, DL; Wu, ZC; Chen, YC; Zhang, WM
刊名	PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2
	2009
页码	278-281
关键词	Aquilaria Sinensis Endophytic Fungus NoduliSp.rium Sp. Extract Cytotoxicity
英文摘要	Nodulisporium sp. A4, an endophytic fungus isolated from the traditional Chinese medicinal plant Aquilaria sinensis (Lour.) Gilg, had been fermented and the culture broth and mycelia were extracted with organic solvent respectively. CCK-8 assay was used to test the cytotoxic effects of the extracts, and the results showed that both the extracts exhibited cytotoxicity on NCI-H460 and SF-268 cell lines in vitro. The culture broth and mycelia extracts were roughly fractionated by Si-gel column chromatography, 20 and 16 fractions were obtained respectively. All the fractions were submitted to cytotoxicity assay. Fractions Fr7, Fr13 (from the culture broth extract) and Fr6', Fr9', Fr13' (from the mycelia extract) were found to be the main potential active parts. This result provided the basis for the fractionation of cytotoxic natural products in the next studies, as well as giving the possibility to develop and utilise the medicinal endophytic fungi from the A. sinensis.
学科主题	Integrative & Complementary Medicine ; Medicine, General & Internal ; Pharmacology & Pharmacy
URL标识	查看原文
资助项目	海洋生物
公开日期	2011-07-03
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/5382]
专题	南海海洋研究所_海洋生物
推荐引用方式 GB/T 7714	Li, DL,Wu, ZC,Chen, YC,et al. Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg[J]. PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2,2009:278-281.
APA	Li, DL,Wu, ZC,Chen, YC,&Zhang, WM.(2009).Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg.PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2,278-281.
MLA	Li, DL,et al."Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg".PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2 (2009):278-281.