Asymmetric cyanosilylation of ketones catalyzed by bifunctional chiral N-oxide titanium complex catalysts

	Asymmetric cyanosilylation of ketones catalyzed by bifunctional chiral N-oxide titanium complex catalysts
	Shen, YC ; Feng, XM ; Li, Y ; Zhang, GL ; Jiang, YZ
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2004
期号	1 页码:129_137
关键词	asymmetric catalysis asymmetric synthesis enantioselectivity ketones N O ligands
ISSN号	1434-193X
通讯作者	Shen, YC, Sichuan Univ, Coll Chem, Sichuan Key LGreen Chem & Technol, Chengdu 610064, Peoples R China.
产权排序	3
中文摘要	A new bifunctional catalytic system based on chiral N-oxide titanium complexes has been used for the asymmetric cyano-silylation of ketones. Screening of a variety of chiral N-oxide metal complexes resulted in (1R,2S)-1-(2'-pyridylmethyl)-2-(diphenylhydroxymethyl)pyrrolidine N-oxide titanium complex, which gave O-TMS cyanohydrins in good yields with enantiomeric excesses of up to 69%. A catalytic cycle based on experimental phenomena and studies was proposed to explain the origin of the asymmetric induction. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).
学科主题	Chemistry, Organic
收录类别	SCI
语种	英语
WOS记录号	WOS:000187676800014
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/17491]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Shen, YC,Feng, XM,Li, Y,et al. Asymmetric cyanosilylation of ketones catalyzed by bifunctional chiral N-oxide titanium complex catalysts[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2004(1):129_137.
APA	Shen, YC,Feng, XM,Li, Y,Zhang, GL,&Jiang, YZ.(2004).Asymmetric cyanosilylation of ketones catalyzed by bifunctional chiral N-oxide titanium complex catalysts.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(1),129_137.
MLA	Shen, YC,et al."Asymmetric cyanosilylation of ketones catalyzed by bifunctional chiral N-oxide titanium complex catalysts".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .1(2004):129_137.