Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice

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	Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice
	Cai, W; Xiao, C; Wu, QP; Tan, JB; Yang, XB; Zhang, JM; xiaochun960@hotmail.com; 13823320821@139.com
刊名	ARCHIVES OF PHARMACAL RESEARCH
	2012
卷号	35 期号:10 页码:1793-1801
关键词	Ganoderma Lucidum Polysaccharides Hypoglycemic Activity Type 2 Diabetes Mellitus
ISSN号	0253-6269
英文摘要	Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administered for 7 days in type 2 diabetic mice. The mice were randomly divided into four groups (8 mice/group): normal control group, diabetic control group, low-dose GLP-treated diabetic group (50 mg/kg/d), and high-dose GLP-treated diabetic group (100 mg/kg/d). Diabetes was induced by streptozotocin injection and high-fat dietary feeding. At the end of the study, fasting serum glucose, insulin, body weight (BW) and epididymal white adipose tissue weight were measured. The hepatic mRNA levels of glycogen phosphorylase (GP), fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) genes were determined by real-time polymerase chain reaction. Both doses of GLPs significantly decreased fasting serum glucose, insulin and epididymal fat/BW ratio compared with the diabetic control group (p < 0.05). The hepatic mRNA levels of GP, FBPase, PEPCK and G6Pase were significantly lower in both GLP-treated groups compared with the diabetic control group. Taken together, GLPs significantly decrease fasting serum glucose levels in type 2 diabetic mice in a dose-dependent manner. The decreases in fasting serum glucose levels may be associated with decreased mRNA expression levels of several key enzymes involved in gluconeogenesis and/or glycogenolysis.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
资助项目	LMB
语种	英语
WOS记录号	WOS:000310950500013
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9778]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	xiaochun960@hotmail.com; 13823320821@139.com
推荐引用方式 GB/T 7714	Cai, W,Xiao, C,Wu, QP,et al. Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35(10):1793-1801.
APA	Cai, W.,Xiao, C.,Wu, QP.,Tan, JB.,Yang, XB.,...&13823320821@139.com.(2012).Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice.ARCHIVES OF PHARMACAL RESEARCH,35(10),1793-1801.
MLA	Cai, W,et al."Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice".ARCHIVES OF PHARMACAL RESEARCH 35.10(2012):1793-1801.